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New insights into bacterial adaptation through in vivo and in silico experimental evolution

Thomas Hindré 1 Carole Knibbe 2, 3 Guillaume Beslon 2, 3 Dominique Schneider 1
3 BEAGLE - Artificial Evolution and Computational Biology
LIRIS - Laboratoire d'InfoRmatique en Image et Systèmes d'information, Inria Grenoble - Rhône-Alpes, LBBE - Laboratoire de Biométrie et Biologie Evolutive - UMR 5558
Abstract : Microbiology research has recently undergone major developments that have led to great progress towards obtaining an integrated view of microbial cell function. Microbial genetics, high-throughput technologies and systems biology have all provided an improved understanding of the structure and function of bacterial genomes and cellular networks. However, integrated evolutionary perspectives are needed to relate the dynamics of adaptive changes to the phenotypic and genotypic landscapes of living organisms. Here, we review evolution experiments, carried out both in vivo with microorganisms and in silico with artificial organisms, that have provided insights into bacterial adaptation and emphasize the potential of bacterial regulatory networks to evolve.
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https://hal.inria.fr/hal-00696231
Contributor : Guillaume Beslon <>
Submitted on : Friday, May 11, 2012 - 12:05:18 PM
Last modification on : Wednesday, July 8, 2020 - 12:43:07 PM

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Thomas Hindré, Carole Knibbe, Guillaume Beslon, Dominique Schneider. New insights into bacterial adaptation through in vivo and in silico experimental evolution. Nature Reviews Microbiology, Nature Publishing Group, 2012, 10 (5), pp.352-365. ⟨10.1038/nrmicro2750⟩. ⟨hal-00696231⟩

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