This paper deals with the two-dimensional bin packing problem with conflicts (BPC-2D). Given a finite set of rectangular items, an unlimited number of rectangular bins and a conflict graph, the goal is to find a conflict-free packing of the items minimizing the number of bins used. In this paper, we propose a new framework based on a tree-decomposition for solving this problem. It proceeds by decomposing a BPC-2D instance into subproblems to be solved independently. Applying this decomposition method is not straightforward, since merging partial solutions is hard. Several heuristic strategies are proposed to make an effective use of the decomposition. Computational experiments show the practical effectiveness of our approach.