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Topology drives calcium wave propagation in 3D astrocyte networks

Jules Lallouette 1, * Hugues Berry 2, 3, 1, *
* Corresponding author
1 BEAGLE - Artificial Evolution and Computational Biology
LBBE - Laboratoire de Biométrie et Biologie Evolutive - UMR 5558, Inria Grenoble - Rhône-Alpes, LIRIS - Laboratoire d'InfoRmatique en Image et Systèmes d'information
Abstract : Glial cells are non-neuronal cells that constitute the majority of cells in the human brain and significantly modulate information processing via permanent cross-talk with the neurons. Astrocytes are also themselves inter-connected as networks and communicate via chemical wave propagation. How astrocyte wave propagation depends on the local prop- erties of the astrocyte networks is however unknown. In the present work, we investigate the influence of the character- istics of the network topology on wave propagation. Using a model of realistic astrocyte networks (> 1000 cells em- bedded in a 3d space), we show that the major classes of propagations reported experimentally can be emulated by a mere variation of the topology. Our study indicates that calcium wave propagation is favored when astrocyte connec- tions are limited by the distance between the cells, which means that propagation is better when the mean-shortest path of the network is larger. This unusual property sheds new light on consistent reports that astrocytes in vivo tend to restrict their connections to their nearest neighbors
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https://hal.inria.fr/hal-00758998
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Submitted on : Thursday, November 29, 2012 - 4:58:28 PM
Last modification on : Wednesday, July 8, 2020 - 12:43:08 PM
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  • HAL Id : hal-00758998, version 1

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Jules Lallouette, Hugues Berry. Topology drives calcium wave propagation in 3D astrocyte networks. European Conference on Complex Systems 2012, 2012, Bruxelles, Belgium. pp.453-463. ⟨hal-00758998⟩

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