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Chronic treatment with myo-inositol reduces white adipose tissue accretion and improves insulin sensitivity in female mice

Marine L Croze 1 Roxane E Vella 1 Nicolas J Pillon 1 Hédi A Soula 1, 2 Lilas Hadji 1 Michel Guichardant 1 Christophe O Soulage 1
2 BEAGLE - Artificial Evolution and Computational Biology
LIRIS - Laboratoire d'InfoRmatique en Image et Systèmes d'information, Inria Grenoble - Rhône-Alpes, LBBE - Laboratoire de Biométrie et Biologie Evolutive - UMR 5558
Abstract : Type 2 diabetes is a complex disease characterized by a state of insulin resistance in peripheral tissues such as skeletal muscle, adipose tissue or liver. Some inositol isomers have been reported to possess insulin-mimetic activity and to be efficient in lowering blood glucose level. The aim of the present study was to assess in mice the metabolic effects of a chronic treatment with myo-inositol, the most common stereoisomer of inositol. Mice given myo-inositol treatment (0.9 or 1.2 mg g(-1) day(-1), 15 days, orally or intraperitoneally) exhibited an improved glucose tolerance due to a greater insulin sensitivity. Mice treated with myo-inositol exhibited a decreased white adipose tissue accretion (-33%, P<.005) compared with controls. The decrease in white adipose tissue deposition was due to a decrease in adipose cell volume (-33%, P<.05), while no change was noticed in total adipocyte number. In skeletal muscle, in vivo as well as ex vivo myo-inositol treatment increased protein kinase B/Akt phosphorylation under baseline and insulin-stimulated conditions, suggesting a synergistic action of myo-inositol treatment and insulin on proteins of the insulin signalling pathway. Myo-inositol could therefore constitute a viable nutritional strategy for the prevention and/or treatment of insulin resistance and type 2 diabetes.
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Submitted on : Friday, November 30, 2012 - 6:43:48 PM
Last modification on : Wednesday, July 8, 2020 - 12:43:07 PM

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Marine L Croze, Roxane E Vella, Nicolas J Pillon, Hédi A Soula, Lilas Hadji, et al.. Chronic treatment with myo-inositol reduces white adipose tissue accretion and improves insulin sensitivity in female mice. Journal of Nutritional Biochemistry, Elsevier, 2013, 24 (2), pp.457-66. ⟨10.1016/j.jnutbio.2012.01.008⟩. ⟨hal-00759518⟩

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