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The Effect of Membrane Receptor Clustering on Spatio- temporal Cell Signalling Dynamics

Bertrand Caré 1, 2, 3, * Hedi Soula 1, 2, *
* Corresponding author
1 BEAGLE - Artificial Evolution and Computational Biology
LIRIS - Laboratoire d'InfoRmatique en Image et Systèmes d'information, Inria Grenoble - Rhône-Alpes, LBBE - Laboratoire de Biométrie et Biologie Evolutive - UMR 5558
Abstract : Membrane receptors allow the cell to respond to changes in the composition of its external medium. The ligand-receptor interaction is the core of the signalling process and may be greatly influenced by the spatial configuration of receptors. As growing pieces of evidence suggest that receptors are not homogeneously spread on the cell surface, but tend to form clusters, we propose to investigate the implication of receptor clustering on ligand binding kinetics using a computational individual-based model. The model simulates the activation of receptors distributed in clusters or uniformly spread. The tracking of binding events allows the analysis of the effect of receptor clustering through the autocorrelation of the receptor activation signal and the empirical time distributions of binding events, which are still unreachable with in vitro or in vivo experiments. Results show that the apparent affinity of clustered receptors is decreased. Additionally, receptor occupation becomes spatially and temporally correlated, as clustering creates platforms of coherently activated receptors. Changes in the spatial characteristics of a signalling system at the microscopic scale globally affect its function in time and space.
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https://hal.inria.fr/hal-00759519
Contributor : Hedi Soula <>
Submitted on : Friday, November 30, 2012 - 6:48:14 PM
Last modification on : Wednesday, July 8, 2020 - 12:43:07 PM

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Bertrand Caré, Hedi Soula. The Effect of Membrane Receptor Clustering on Spatio- temporal Cell Signalling Dynamics. Proceedings of the 9th International Conference on Information Processing in Cells and Tissues 2012, 2012, Cambridge, United Kingdom. pp.50-61, ⟨10.1007/978-3-642-28792-3_8⟩. ⟨hal-00759519⟩

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