Tumor regression with a combination of drugs interfering with the tumor metabolism: efficacy of hydroxycitrate, lipoic acid and capsaicin.

Laurent Schwartz 1, 2 Adeline Guais Maurice Israël 3 Bernard Junod Jean-Marc Steyaert 1, 4 Elisabetta Crespi Gianfranco Baronzio Mohammad Abolhassani
4 AMIB - Algorithms and Models for Integrative Biology
LIX - Laboratoire d'informatique de l'École polytechnique [Palaiseau], LRI - Laboratoire de Recherche en Informatique, UP11 - Université Paris-Sud - Paris 11, Inria Saclay - Ile de France, Polytechnique - X, CNRS - Centre National de la Recherche Scientifique : UMR8623
Abstract : Cellular metabolic alterations are now well described as implicated in cancer and some strategies are currently developed to target these different pathways. In previous papers, we demonstrated that a combination of molecules (namely alpha-lipoic acid and hydroxycitrate, i.e. Metabloc™) targeting the cancer metabolism markedly decreased tumor cell growth in mice. In this work, we demonstrate that the addition of capsaicin further delays tumor growth in mice in a dose dependant manner. This is true for the three animal model tested: lung (LLC) cancer, bladder cancer (MBT-2) and melanoma B16F10. There was no apparent side effect of this ternary combination. The addition of a fourth drug (octreotide) is even more effective resulting in tumor regression in mice bearing LLC cancer. These four compounds are all known to target the cellular metabolism not its DNA. The efficacy, the apparent lack of toxicity, the long clinical track records of these medications in human medicine, all points toward the need for a clinical trial. The dramatic efficacy of treatment suggests that cancer may simply be a disease of dysregulated cellular metabolism.
Type de document :
Article dans une revue
Investigational New Drugs, Springer Verlag, 2012, epub ahead of print. 〈10.1007/s10637-012-9849-z〉
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Soumis le : jeudi 6 décembre 2012 - 10:08:31
Dernière modification le : jeudi 11 janvier 2018 - 06:23:08

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Laurent Schwartz, Adeline Guais, Maurice Israël, Bernard Junod, Jean-Marc Steyaert, et al.. Tumor regression with a combination of drugs interfering with the tumor metabolism: efficacy of hydroxycitrate, lipoic acid and capsaicin.. Investigational New Drugs, Springer Verlag, 2012, epub ahead of print. 〈10.1007/s10637-012-9849-z〉. 〈hal-00761761〉

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