Long-term outcome of 32 patients with chorea and systemic lupus erythematosus or antiphospholipid antibodies.

Abstract : OBJECTIVE: The aim of this work was to describe chorea during systemic lupus erythematosus or antiphospholipid antibodies and its long-term outcome. METHODS: We retrospectively analyzed clinical features, laboratory findings, imaging characteristics, and outcome in a series of 32 patients. RESULTS: Most patients were women (28 of 32), and mean age at onset of chorea was 20.6 (9-62) years. Chorea was inaugural for 28 patients. Improvement was observed with various treatments. During follow-up (12.2 ± 11.3 years), severe manifestations of systemic lupus erythematosus were rare. Antiphospholipid antibodies were repeatedly positive for 90% of the patients. Twelve patients developed arterial thrombosis. Prophylactic treatment with antithrombotic therapy might reduce the risk of further thrombosis (8% versus 57%; P = 0.01). Cardiac valvulopathy occurred in 22 patients during follow-up. Chorea relapsed in 8 cases. CONCLUSIONS: Chorea had a good outcome in itself. This long-term follow-up shows, for the first time, that these patients have substantial risk for further arterial thrombosis.
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Movement Disorders, Wiley, 2011, 26 (13), pp.2422-7. 〈10.1002/mds.23863〉
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https://hal.inria.fr/hal-00795754
Contributeur : Olivier Colliot <>
Soumis le : jeudi 28 février 2013 - 19:26:27
Dernière modification le : mercredi 21 mars 2018 - 18:57:48

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Peggy Reiner, Damien Galanaud, Gaëlle Leroux, Marie Vidailhet, Julien Haroche, et al.. Long-term outcome of 32 patients with chorea and systemic lupus erythematosus or antiphospholipid antibodies.. Movement Disorders, Wiley, 2011, 26 (13), pp.2422-7. 〈10.1002/mds.23863〉. 〈hal-00795754〉

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