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De la modélisation comme poésie. La modélisation de systèmes biologiques complexes vue par deux modélisateurs

Hugues Berry 1, 2, 3 Guillaume Beslon 2, 3
2 BEAGLE - Artificial Evolution and Computational Biology
LIRIS - Laboratoire d'InfoRmatique en Image et Systèmes d'information, Inria Grenoble - Rhône-Alpes, LBBE - Laboratoire de Biométrie et Biologie Evolutive - UMR 5558
Abstract : Questioning the status and usage of models in science is common practice, but, strangely, has hardly been tackled by the modelers themselves. Yet, this issue should be of prime concern to modelers, especially when they use their models to interact with other disciplinary fields. In this chapter, we, as modelers developing individual-based models in order to produce new knowledge in biology, question our own practice of modelling. This leads us to consider our models as scientific instruments, thence to propose a way to use them as a fair practice to match this status. We deduce several con- straints related to the usage of models that we arrange as rules of a code of good practice for the modeler. In particular, just as any instrument borrows technologies in a given field to investigate another field, we argue that the major issue in modeling is not really the epistemological status of the models, but rather the interdisciplinarity that naturally emerges from their usage. We illustrate our points by an example in microbiology : the positioning by intra- cellular reaction-diffusion mechanisms, of the division septum in E. coli. This example shows how the production of knowledge from a model necessitate to leverage a diverse set of tools from various disciplinary fields, to confront them and have them interact in order to include them in the model before parametrizing and analyzing it and in fine, produce new knowledge. In con- clusion, we focus on the position of the modeler within the virtuous circle hat links the model to its modeled object. We suggest in particular that the modeler is more than an actor in this circle, it actually embodies it.
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Contributor : Hugues Berry <>
Submitted on : Thursday, April 18, 2013 - 11:47:31 PM
Last modification on : Wednesday, July 8, 2020 - 12:43:07 PM


  • HAL Id : hal-00815550, version 1


Hugues Berry, Guillaume Beslon. De la modélisation comme poésie. La modélisation de systèmes biologiques complexes vue par deux modélisateurs. Franck Varenne and Marc Silberstein. Modéliser & simuler. Epistémologies et pratiques de la modélisation et de la simulation, 1, Editions Matériologiques, Paris, 2013, 978-2-919694-19-8. ⟨hal-00815550⟩



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