TFM-Explorer: mining cis-regulatory regions in genomes

Tonon Laurie 1 Hélène Touzet 1, 2 Jean-Stéphane Varré 1, 2
1 BONSAI - Bioinformatics and Sequence Analysis
LIFL - Laboratoire d'Informatique Fondamentale de Lille, Inria Lille - Nord Europe
Abstract : DNA-binding transcription factors (TFs) play a central role in transcription regulation, and computational approaches that help in elucidating complex mechanisms governing this basic biological process are of great use. In this perspective, we present the TFM-Explorer web server that is a toolbox to identify putative TF binding sites within a set of upstream regulatory sequences of genes sharing some regulatory mechanisms. TFM-Explorer finds local regions showing overrepresentation of binding sites. Accepted organisms are human, mouse, rat, chicken and drosophila. The server employs a number of features to help users to analyze their data: visualization of selected binding sites on genomic sequences, and selection of cis-regulatory modules. TFM-Explorer is available at http://bioinfo.lifl.fr/TFM.
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NAR Web Server Issue, Oxford, 2010, 38 (S2), pp.W286-W292. 〈10.1093/nar/gkq473〉
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https://hal.inria.fr/hal-00823465
Contributeur : Jean-Stéphane Varré <>
Soumis le : vendredi 17 mai 2013 - 09:24:09
Dernière modification le : jeudi 11 janvier 2018 - 06:23:37

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Tonon Laurie, Hélène Touzet, Jean-Stéphane Varré. TFM-Explorer: mining cis-regulatory regions in genomes. NAR Web Server Issue, Oxford, 2010, 38 (S2), pp.W286-W292. 〈10.1093/nar/gkq473〉. 〈hal-00823465〉

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