Cardiac arrhythmia induced by hypothermia in a cardiac model in vitro

Abstract : The neurological damage after cardiac arrest (CA) constitutes a big challenge of hospital discharge since years. The therapeutic hypothermia therapy (34°C-32°C) has shown its benefit to reduce cerebral oxygen demand and improve neurological outcomes after the cardiac arrest. Despite the fact that induced hypothermia after CA has been shown to increase the hospital survival rate, it can have many adverse effects, among which the cardiac arrhythmia generation represents an important part (up to 34%, according different clinical studies). Compared to studies in vivo, cardiac culture in vitro provides a better spatial resolution at cellular level, which could bring some insights of the mechanism of post-hypothermia arrhythmia (PHA) generation
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Binbin Xu, Sabir Jacquir, Stéphane Binczak, Oriol Pont, Hussein Yahia. Cardiac arrhythmia induced by hypothermia in a cardiac model in vitro. 40th International Congress on Electrocardiology, University of Glasgow, International Society of Electrocardiology, Aug 2013, Glasgow, United Kingdom. ⟨hal-00823857v2⟩

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