Characteristics of binding sites of intergenic, intronic and exonic miRNAs with mRNAs of oncogenes coding intronic miRNAs

Olga Berillo 1 Assel Issabekova 1 Mireille Regnier 2, 3 Anatoly Ivashchenko 1
2 AMIB - Algorithms and Models for Integrative Biology
LIX - Laboratoire d'informatique de l'École polytechnique [Palaiseau], LRI - Laboratoire de Recherche en Informatique, UP11 - Université Paris-Sud - Paris 11, Inria Saclay - Ile de France
Abstract : The interaction of 784 intergenic (ig-miRNA), 686 intronic (in-miRNA) and 49 exonic miRNAs (ex-miRNA) with mRNAs of 51 oncogenes coding in-miRNAs was investigated. Out of the studied genes, 44 were targets for 94 ig-miRNAs, 29 were targets for 44 in-miRNAs and 7 were targets for 7 ex-miRNAs. The density of miRNA binding sites was higher in 5'-untranslated regions than it was in coding sequences and 3'-untranslated regions. Three types of miRNA interaction with mRNA were revealed: 5'-dominant canonical, 3'-compensatory and complementary types. In-miRNAs do not interact with mRNAs of host genes (where in-miRNA is encoded). Linkage between some mRNAs of genes encodes in-miRNAs via other in-miRNAs was revealed. These data promote the understanding of interaction mechanism of miRNA with mRNA genes participating in gastrointestinal and breast cancers.
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Olga Berillo, Assel Issabekova, Mireille Regnier, Anatoly Ivashchenko. Characteristics of binding sites of intergenic, intronic and exonic miRNAs with mRNAs of oncogenes coding intronic miRNAs. African Journal of Biotechnology, Academic Journals, 2013, 12 (10), pp.1016-1024. ⟨http://www.academicjournals.org/ajb/PDF/pdf2013/6Mar/Berillo%20et%20al.pdf⟩. ⟨10.5897/AJB12.2054⟩. ⟨hal-00825020⟩

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