Enhancing the Reproducibility of Group Analysis with Randomized Brain Parcellations

Abstract : Neuroimaging group analyses are used to compare the inter-subject variability observed in brain organization with behavioural or genetic variables and to assess risks factors of brain diseases. The lack of stability and of sensitivity of current voxel-based analysis schemes may however lead to non-reproducible results. A new approach is introduced to overcome the limitations of standard methods, in which active voxels are detected according to a consensus on several random parcellations of the brain images, while a permutation test controls the false positive risk. Both on syntetic and real data, this approach shows higher sensitivity, better recovery and higher reproducibility than standard methods and succeeds in detecting a significant association in an imaging-genetic study between a genetic variant next to the COMT gene and a region in the left thalamus on a functional Magnetic Resonance Imaging contrast.
Type de document :
Communication dans un congrès
MICCAI - 16th International Conference on Medical Image Computing and Computer Assisted Intervention - 2013, Sep 2013, Nagoya, Japan. 2013
Liste complète des métadonnées

Littérature citée [14 références]  Voir  Masquer  Télécharger

https://hal.inria.fr/hal-00832616
Contributeur : Benoit Da Mota <>
Soumis le : mardi 11 juin 2013 - 09:43:14
Dernière modification le : jeudi 29 mars 2018 - 10:32:02
Document(s) archivé(s) le : jeudi 12 septembre 2013 - 04:06:19

Fichier

paper397.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

  • HAL Id : hal-00832616, version 1

Collections

Citation

Benoit Da Mota, Virgile Fritsch, Gaël Varoquaux, Vincent Frouin, Jean-Baptiste Poline, et al.. Enhancing the Reproducibility of Group Analysis with Randomized Brain Parcellations. MICCAI - 16th International Conference on Medical Image Computing and Computer Assisted Intervention - 2013, Sep 2013, Nagoya, Japan. 2013. 〈hal-00832616〉

Partager

Métriques

Consultations de la notice

385

Téléchargements de fichiers

206