Modelling adipocytes size distribution

H. A. Soula 1, 2 H. Julienne 2 C O Soulage 2 A Géloën 2
1 BEAGLE - Artificial Evolution and Computational Biology
LIRIS - Laboratoire d'InfoRmatique en Image et Systèmes d'information, Inria Grenoble - Rhône-Alpes, LBBE - Laboratoire de Biométrie et Biologie Evolutive, CarMeN - Cardiovasculaire, métabolisme, diabétologie et nutrition
Abstract : Adipocytes are cells whose task is to store excess energy as lipid droplets in their cytoplasm. Adipocytes can adapt their size according to the lipid amount to be stored. Adipocyte size variation can reach one order of magnitude inside the same organism which is unique among cells. A striking feature in adipocytes size distribution is the lack of characteristic size since typical size distributions are bimodal. Since energy can be stored and retrieved and adipocytes are responsible for these lipid fluxes, we propose a simple model of size-dependent lipid fluxes that is able to predict typical adipocytes size distribution.
Type de document :
Article dans une revue
Journal of Theoretical Biology, Elsevier, 2013, 332, pp.89-95. 〈10.1016/j.jtbi.2013.04.025〉
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https://hal.inria.fr/hal-00850474
Contributeur : Hedi Soula <>
Soumis le : mardi 6 août 2013 - 17:14:12
Dernière modification le : mardi 17 juillet 2018 - 15:50:08

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H. A. Soula, H. Julienne, C O Soulage, A Géloën. Modelling adipocytes size distribution. Journal of Theoretical Biology, Elsevier, 2013, 332, pp.89-95. 〈10.1016/j.jtbi.2013.04.025〉. 〈hal-00850474〉

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