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Modelling adipocytes size distribution

H. A. Soula 1, 2 H. Julienne 2 Christophe Soulage 2 Alain Geloen 2
1 BEAGLE - Artificial Evolution and Computational Biology
LBBE - Laboratoire de Biométrie et Biologie Evolutive - UMR 5558, Inria Grenoble - Rhône-Alpes, LIRIS - Laboratoire d'InfoRmatique en Image et Systèmes d'information
Abstract : Adipocytes are cells whose task is to store excess energy as lipid droplets in their cytoplasm. Adipocytes can adapt their size according to the lipid amount to be stored. Adipocyte size variation can reach one order of magnitude inside the same organism which is unique among cells. A striking feature in adipocytes size distribution is the lack of characteristic size since typical size distributions are bimodal. Since energy can be stored and retrieved and adipocytes are responsible for these lipid fluxes, we propose a simple model of size-dependent lipid fluxes that is able to predict typical adipocytes size distribution.
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Contributor : Hedi Soula Connect in order to contact the contributor
Submitted on : Tuesday, August 6, 2013 - 5:14:12 PM
Last modification on : Tuesday, July 20, 2021 - 5:20:04 PM



H. A. Soula, H. Julienne, Christophe Soulage, Alain Geloen. Modelling adipocytes size distribution. Journal of Theoretical Biology, Elsevier, 2013, 332, pp.89-95. ⟨10.1016/j.jtbi.2013.04.025⟩. ⟨hal-00850474⟩



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