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Modélisation de la diffusion-réaction dans les milieux intracellulaires encombrés

Hugues Berry 1, 2, 3, * 
* Corresponding author
2 BEAGLE - Artificial Evolution and Computational Biology
LIRIS - Laboratoire d'InfoRmatique en Image et Systèmes d'information, Inria Grenoble - Rhône-Alpes, LBBE - Laboratoire de Biométrie et Biologie Evolutive - UMR 5558
Abstract : Because macromolecules in biological cells interact only when they meet, the way by which they actually move has deep impact on the cell inner life. More often than not, biochemists get rid of this issue by considering that cell biochemical and signaling pathways are static objects with no real spatial dependency. Experimental as well as most modeling approaches thus rely on mean-field equations ("mass-action laws'') which assume that intracellular spaces are diluted, perfectly stirred and spatially homogeneous. However, single-cell (and sometimes single tracker) experiments consistently report that diffusion in most intracellular compartments (membranes, cytoplasm, nucleus) is anomalous and sub-diffusive (i.e. not Brownian). Albeit the underlying causes for these behaviors are still debated, physical obstruction of the molecule movements due to obstacles is recurrently evoked. In any case, these observations indicate that, fundamentally, intracellular spaces are spatially inhomogeneous and poorly connected. I introduce here the main methods, discrete or continuous, to model the influence of these properties: individual-based models, space-dependent reaction-diffusion, fractional subdiffusion-reaction.
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Submitted on : Thursday, September 5, 2013 - 10:49:14 PM
Last modification on : Tuesday, October 25, 2022 - 4:17:13 PM


  • HAL Id : hal-00858738, version 1


Hugues Berry. Modélisation de la diffusion-réaction dans les milieux intracellulaires encombrés. Glade, Nicolas and Stéphanou, Angélique. Le vivant discret et continu, Editions Matériologiques, pp.241-266, 2013, 978-2-919694-24-2. ⟨hal-00858738⟩



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