Skip to Main content Skip to Navigation
Book sections

Modélisation de la diffusion-réaction dans les milieux intracellulaires encombrés

Hugues Berry 1, 2, 3, *
* Corresponding author
2 BEAGLE - Artificial Evolution and Computational Biology
LBBE - Laboratoire de Biométrie et Biologie Evolutive - UMR 5558, Inria Grenoble - Rhône-Alpes, LIRIS - Laboratoire d'InfoRmatique en Image et Systèmes d'information
Abstract : Because macromolecules in biological cells interact only when they meet, the way by which they actually move has deep impact on the cell inner life. More often than not, biochemists get rid of this issue by considering that cell biochemical and signaling pathways are static objects with no real spatial dependency. Experimental as well as most modeling approaches thus rely on mean-field equations ("mass-action laws'') which assume that intracellular spaces are diluted, perfectly stirred and spatially homogeneous. However, single-cell (and sometimes single tracker) experiments consistently report that diffusion in most intracellular compartments (membranes, cytoplasm, nucleus) is anomalous and sub-diffusive (i.e. not Brownian). Albeit the underlying causes for these behaviors are still debated, physical obstruction of the molecule movements due to obstacles is recurrently evoked. In any case, these observations indicate that, fundamentally, intracellular spaces are spatially inhomogeneous and poorly connected. I introduce here the main methods, discrete or continuous, to model the influence of these properties: individual-based models, space-dependent reaction-diffusion, fractional subdiffusion-reaction.
Complete list of metadata

https://hal.inria.fr/hal-00858738
Contributor : Hugues Berry Connect in order to contact the contributor
Submitted on : Thursday, September 5, 2013 - 10:49:14 PM
Last modification on : Tuesday, July 20, 2021 - 5:20:04 PM

Identifiers

  • HAL Id : hal-00858738, version 1

Citation

Hugues Berry. Modélisation de la diffusion-réaction dans les milieux intracellulaires encombrés. Glade, Nicolas and Stéphanou, Angélique. Le vivant discret et continu, Editions Matériologiques, pp.241-266, 2013, 978-2-919694-24-2. ⟨hal-00858738⟩

Share

Metrics

Record views

546