Adipocyte triglyceride turnover and lipolysis in lean and overweight subjects.

Abstract : Human obesity is associated with decreased triglyceride turnover and impaired lipolysis in adipocytes. We determined whether such defects also occur in subjects with only moderate increase in fat mass. Human abdominal subcutaneous adipose tissue was investigated in healthy, nonobese subjects [body mass index (BMI) > 17 kg/m(2) and BMI < 30 kg/m(2)]. Triglyceride age, reflecting lipid turnover, was examined in 41 subjects by assessing the incorporation of atmospheric (14)C into adipose lipids. Adipocyte lipolysis was examined as the ability of lipolytic agents to stimulate glycerol release in 333 subjects. Adipocyte triglyceride age was markedly increased in overweight (BMI ≥ 25 kg/m(2)) compared with lean subjects (P = 0.017) with triglyceride T1/2 of 14 and 9 months, respectively (P = 0.04). Triglyceride age correlated positively with BMI (P = 0.002) but not with adipocyte volume (P = 0.2). Noradrenaline-, isoprenaline- or dibutyryl cyclic AMP-induced lipolysis was inversely correlated with triglyceride age (P < 0.01) and BMI (P < 0.0001) independently of basal lipolysis, gender, and nicotine use. Current, but not the highest or lowest BMI in adult life, correlated significantly (inversely) with lipolysis. In conclusion, adipocyte triglyceride turnover and lipolytic activity are decreased in overweight subjects and reflect the current BMI status. These changes may confer an increased risk for early development and/or maintenance of excess body fat.
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Journal of Lipid Research, American Society for Biochemistry and Molecular Biology, 2013, 54 (10), pp.2909-2913. 〈10.1194/jlr.M040345〉
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Soumis le : lundi 30 septembre 2013 - 10:54:23
Dernière modification le : mercredi 11 avril 2018 - 01:56:14

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Mikael Rydén, Daniel P Andersson, Samuel Bernard, Kirsty Spalding, Peter Arner. Adipocyte triglyceride turnover and lipolysis in lean and overweight subjects.. Journal of Lipid Research, American Society for Biochemistry and Molecular Biology, 2013, 54 (10), pp.2909-2913. 〈10.1194/jlr.M040345〉. 〈hal-00867570〉

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