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A first principles calculation of the oxygen uptake in the human pulmonary acinus at maximal exercise

Abstract : t has recently been shown that the acinus can have a reduced efficiency due to a "screening effect" governed by the ratio of oxygen diffusivity to membrane permeability, the gas flow velocity, as well as the size and configuration of the acinus. We present here a top to bottom calculation of the functioning of a machine acinus at exercise that takes this screening effect into account. It shows that, given the geometry and the breathing dynamics of real acini, respiration can be correlated to a single equivalent parameter that we call the integrative permeability. In particular we find that both VO2 ,max and PAO2 depend on this permeability in a non-linear manner. Numerical solutions of dynamic convection-diffusion equations indicate that only a narrow range of permeability values is compatible with the experimental measurements of P AO2 and VO2 ,max . These permeability values are significantly smaller than those found in the literature. In a second step, we present a new type of evaluation of the diffusive permeability, yielding values compatible with the top to bottom approach, but smaller than the usual morphometric value.
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https://hal.inria.fr/hal-00918646
Contributor : Gregory Arbia <>
Submitted on : Friday, December 13, 2013 - 8:38:31 PM
Last modification on : Wednesday, September 23, 2020 - 4:32:48 AM

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Aurélie Foucquier, Marcel Filoche, Andre Auto Moreira, José Soares Andrade, Grégory Arbia, et al.. A first principles calculation of the oxygen uptake in the human pulmonary acinus at maximal exercise. Respiratory Physiology and Neurobiology, Elsevier, 2013, 185 (3), pp.625-638. ⟨10.1016/j.resp.2012.10.013⟩. ⟨hal-00918646⟩

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