Reproduction of EEG power spectrum over frontal region during the propofol-induced general anesthesia

Meysam Hashemi 1, * Axel Hutt 1 Jamie Sleigh 2 Peter Beim Graben 3
* Corresponding author
1 NEUROSYS - Analysis and modeling of neural systems by a system neuroscience approach
Inria Nancy - Grand Est, LORIA - AIS - Department of Complex Systems, Artificial Intelligence & Robotics
Abstract : The present work aims to reproduce certain changes observed experimentally in the EEG power spectrum over the frontal head region during general anesthesia induced by propofol. These observations include increased delta (0-4 Hz) and alpha (8-12 Hz) activities. We extend a previous cortical model and study a neuronal population model of a single thalamo-cortical module consisting of three different populations of neurons, namely cortical excitatory neurons, thalamocortical relay neurons and inhibitory thalamic reticular neurons (Fig. 1). Each module obeys a neural mass model. The cortical inhibitory population is neglected in our model to reveal the effect of propofol action in the thalamus. Our model describes well the characteristic spectral changes observed experimentally within the delta- and alpha- frequency bands in frontal and occipital electrodes with increasing concentration of propofol.
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Poster communications
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Meysam Hashemi, Axel Hutt, Jamie Sleigh, Peter Beim Graben. Reproduction of EEG power spectrum over frontal region during the propofol-induced general anesthesia. Twenty Third Annual Computational Neuroscience Meeting: CNS - 2014, Jul 2014, Québec City, Canada. 15 (Suppl 1), pp.P211, 2014, ⟨10.1186/1471-2202-15-S1-P211⟩. ⟨hal-01026526⟩

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