In silico assessment of drugs effects on human embryonic stem cells derived cardiomyocytes electrical activity

Emanuela Abbate 1 Nejib Zemzemi 1 Yves Coudière 2, 1 Jean-Frédéric Gerbeau 3
1 CARMEN - Modélisation et calculs pour l'électrophysiologie cardiaque
IHU-LIRYC, IMB - Institut de Mathématiques de Bordeaux, Inria Bordeaux - Sud-Ouest
3 REO - Numerical simulation of biological flows
LJLL - Laboratoire Jacques-Louis Lions, Inria Paris-Rocquencourt, UPMC - Université Pierre et Marie Curie - Paris 6
Abstract : Computational modeling and simulation is extensively used to investigate diseases in cardiac electrophysiological activity and also drug effects, side effects and interactions. Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) have been recently considered as a promising tool in regenerative medicine: their major role in repairing damaged tissue is due to pluripotency and ability to differentiate. These pluripotent cells are also used in early stages of drugs development. Pharmaceutical companies use the MultiElectrode Array (MEA) device in order to perform many in vitro experiments on hESC-CMs. The goal of our study is to derive a mathematical model and to simulate these in vitro experiments.
Type de document :
Communication dans un congrès
LACM 2015 (2nd International Workshop on Latest Advances in Cardiac Modeling), Mar 2015, German Heart Center, Munich, Germany. 2015, 〈https://www.lnm.mw.tum.de/lacm2015/〉
Liste complète des métadonnées

https://hal.inria.fr/hal-01202019
Contributeur : Emanuela Abbate <>
Soumis le : vendredi 18 septembre 2015 - 15:13:34
Dernière modification le : jeudi 11 janvier 2018 - 06:23:41

Identifiants

  • HAL Id : hal-01202019, version 1

Collections

INRIA | IMB | INSMI | UPMC | LJLL | USPC

Citation

Emanuela Abbate, Nejib Zemzemi, Yves Coudière, Jean-Frédéric Gerbeau. In silico assessment of drugs effects on human embryonic stem cells derived cardiomyocytes electrical activity. LACM 2015 (2nd International Workshop on Latest Advances in Cardiac Modeling), Mar 2015, German Heart Center, Munich, Germany. 2015, 〈https://www.lnm.mw.tum.de/lacm2015/〉. 〈hal-01202019〉

Partager

Métriques

Consultations de la notice

401