Aerosols in the lung: multi-domain transport and coupling

Jessica M. Oakes 1, 2 Shawn C. Shadden 2 Céline Grandmont 1 Irene Vignon-Clementel 1
1 REO - Numerical simulation of biological flows
LJLL - Laboratoire Jacques-Louis Lions, Inria Paris-Rocquencourt, UPMC - Université Pierre et Marie Curie - Paris 6
Abstract : In this paper, we present a framework that couples three-dimensional (3D) to one-dimensional (1D) transport models to predict particle deposition in the respiratory airways throughout respiration. During respiration, the time dependent flow rate and particle concentration can be passed between the domains (inspiration: 3D to 1D, expiration: 1D to 3D). This framework enables us to predict particle transport and deposition in the whole lung and throughout both inspiration and expiration.
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Jessica M. Oakes, Shawn C. Shadden, Céline Grandmont, Irene Vignon-Clementel. Aerosols in the lung: multi-domain transport and coupling. 4th International Conference on Computational and Mathematical Biomedical Engineering - CMBE2015, Jun 2015, Cachan, France. ⟨hal-01244582⟩

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