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Donepezil decreases annual rate of hippocampal atrophy in suspected prodromal Alzheimer's disease

Bruno Dubois 1, 2 Marie Chupin 2, 3 Harald Hampel 4 Simone Lista 1 Enrica Cavedo 5 Bernard Croisile 6 Guy Louis Tisserand 6 Jacques Touchon 7 Alain Bonafe 7 Pierre Jean Ousset 8 Amir Ait Ameur 9 Olivier Rouaud 10 Fréderic Ricolfi 11 Alain Vighetto 6 Florence Pasquier 12 Christine Delmaire 13 Mathieu Ceccaldi 14 Nadine Girard 14 Carole Dufouil 15 Stéphane Lehericy 2, 16 Isabelle Tonelli 17 Françoise Duveau 17 Olivier Colliot 2, 3 Line Garnero 2 Marie Sarazin 1, 2 Didier Dormont 2, 3, 16 
Abstract : INTRODUCTION: The purpose of this study was to study the effect of donepezil on the rate of hippocampal atrophy in prodromal Alzheimer's disease (AD). METHODS: A double-blind, randomized, placebo-controlled parallel group design using donepezil (10 mg/day) in subjects with suspected prodromal AD. Subjects underwent two brain magnetic resonance imaging scans (baseline and final visit). The primary efficacy outcome was the annualized percentage change (APC) of total hippocampal volume (left + right) measured by an automated segmentation method. RESULTS: Two-hundred and sixteen only subjects were randomized across 28 French expert clinical sites. In the per protocol population (placebo = 92 and donepezil = 82), the donepezil group exhibited a significant reduced rate of hippocampal atrophy (APC = -1.89%) compared with the placebo group (APC = -3.47%), P < .001. There was no significant difference in neuropsychological performance between treatment groups. DISCUSSION: A 45% reduction of rate of hippocampal atrophy was observed in prodromal AD following 1 year of treatment with donepezil compared with placebo.
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Submitted on : Sunday, January 3, 2016 - 11:39:43 PM
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Bruno Dubois, Marie Chupin, Harald Hampel, Simone Lista, Enrica Cavedo, et al.. Donepezil decreases annual rate of hippocampal atrophy in suspected prodromal Alzheimer's disease. Alzheimer's and Dementia, 2015, 11 (9), pp.1041-1049. ⟨10.1016/j.jalz.2014.10.003⟩. ⟨hal-01249861⟩



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