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Norine: a powerful resource for novel nonribosomal peptide discovery

Maude Pupin 1, 2 Qassim Esmaeel 3 Areski Flissi 1, 2 Yoann Dufresne 1, 2 Philippe Jacques 3 Valérie Leclère 1, 2, 3
2 BONSAI - Bioinformatics and Sequence Analysis
Université de Lille, Sciences et Technologies, Inria Lille - Nord Europe, CRIStAL - Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189, CNRS - Centre National de la Recherche Scientifique
Abstract : Since its first release in 2008, Norine remains the unique resource completely devoted to nonribosomal peptides (NRPs). They are very attractive microbial secondary metabolites, displaying a remarkable diversity of structure and functions. Norine (http://bioinfo.lifl.fr/NRP) includes a database now containing more than 1160 annotated peptides and user-friendly interfaces enabling the querying of the database, through the annotations or the structure of the peptides. Dedicated tools are associated for structural comparison of the compounds and prediction of their biological activities. In this paper, we start by describing the knowledgebase and the dedicated tools. We then present some user cases to show how useful Norine is for the discovery of novel nonribosomal peptides.
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Maude Pupin, Qassim Esmaeel, Areski Flissi, Yoann Dufresne, Philippe Jacques, et al.. Norine: a powerful resource for novel nonribosomal peptide discovery. Synthetic and Systems Biotechnology, KeAi, 2015, ⟨10.1016/j.synbio.2015.11.001⟩. ⟨hal-01250614⟩

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