Slow modulations of high-frequency activity (40-140-Hz) discriminate preictal changes in human focal epilepsy.

Abstract : Recent evidence suggests that some seizures are preceded by preictal changes that start from minutes to hours before an ictal event. Nevertheless an adequate statistical evaluation in a large database of continuous multiday recordings is still missing. Here, we investigated the existence of preictal changes in long-term intracranial recordings from 53 patients with intractable partial epilepsy (in total 531 days and 558 clinical seizures). We describe a measure of brain excitability based on the slow modulation of high-frequency gamma activities (40-140 Hz) in ensembles of intracranial contacts. In prospective tests, we found that this index identified preictal changes at levels above chance in 13.2% of the patients (7/53), suggesting that results may be significant for the whole group (p < 0.05). These results provide a demonstration that preictal states can be detected prospectively from EEG data. They advance understanding of the network dynamics leading to seizure and may help develop novel seizure prediction algorithms.
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Scientific Reports, Nature Publishing Group, 2013, 4, pp.4545
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https://hal.inria.fr/hal-01252648
Contributeur : Olivier Colliot <>
Soumis le : jeudi 7 janvier 2016 - 20:05:15
Dernière modification le : mardi 31 juillet 2018 - 15:00:02

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C Alvarado-Rojas, M Valderrama, A Fouad-Ahmed, H Feldwisch-Drentrup, M Ihle, et al.. Slow modulations of high-frequency activity (40-140-Hz) discriminate preictal changes in human focal epilepsy.. Scientific Reports, Nature Publishing Group, 2013, 4, pp.4545. 〈hal-01252648〉

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