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System and method for interactive patient specific simulation of radiofrequency ablation therapy

Abstract : A method and system for interactive patient-specific simulation of liver tumor ablation is disclosed. A patient-specific anatomical model of the liver and circulatory system of the liver is estimated from 3D medical image data of a patient. A computational domain is generated from the patient-specific anatomical model of the liver. Blood flow in the liver and the circulatory system of the liver is simulated based on the patient-specific anatomical model. Heat diffusion due to ablation is simulated based on a virtual ablation probe position and the simulated blood flow in the liver and the circulatory system of the liver by solving a bio-heat equation for each node on the level-set representation using a Lattice-Boltzmann method (LBM) implementation. Cellular necrosis in the liver is computed based on the simulated heat diffusion. Visualizations of a computed necrosis region and temperature maps of the liver are generated. A user input is interactively received to modify the position of the virtual ablation probe, the heat diffusion and cellular necrosis is re-simulated based on the user input, and the visualizations of the computed necrosis region and the temperature maps are updated
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https://hal.inria.fr/hal-01253710
Contributor : Project-Team Asclepios <>
Submitted on : Monday, January 11, 2016 - 11:47:11 AM
Last modification on : Friday, January 18, 2019 - 1:19:59 AM

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  • HAL Id : hal-01253710, version 1

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Chloé Audigier, Tommaso Mansi, Viorel Mihalef, Ali Kamen, Dorin Comaniciu, et al.. System and method for interactive patient specific simulation of radiofrequency ablation therapy. United States, Patent n° : PCT/US2014/017886. 2014. ⟨hal-01253710⟩

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