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Quantitative analysis of metabolic networks and design of minimal bioreaction models

Abstract : This tutorial paper is concerned with the design of macroscopic bioreaction models on the basis a quantitative analysis of the underlying cell metabolism. The paper starts with a review of two fundamental algebraic techniques for the quantitative analysis of metabolic networks : (i) the decomposition of complex metabolic networks into elementary pathways (or elementary modes), (ii) the metabolic flux analysis which aims at computing the entire intracellular flux distribution from a limited number of flux meaurements. Then it is discussed how these two fundamental techniques can be exploited to design minimal bioreaction models by using a systematic model reduction approach that automatically produces a family of equivalent minimal models which are fully compatible with the underlying metabolism and consistent with the available experimental data. The theory is illustrated with an experimental case-study on CHO cells.
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https://hal.inria.fr/hal-01277922
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Georges Bastin. Quantitative analysis of metabolic networks and design of minimal bioreaction models. Revue Africaine de la Recherche en Informatique et Mathématiques Appliquées, INRIA, 2008, 9. ⟨hal-01277922⟩

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