Diabetes and cognitive decline in a French cohort of patients infected with HIV-1

Abstract : Objective: We investigated the relationship of diabetes and prediabetes with cognitive performances, assessed through raw test and z scores and according to neurocognitive impairment (NCI) classification in a cohort of individuals infected with HIV. Methods: The ANRS CO3 Aquitaine cohort is a prospective hospital-based cohort of HIV-1–infected patients under routine clinical management in 6 public hospitals in southwestern France. Between 2007 and 2009, an ancillary study consisted of a neuropsychological battery of 10 tests at baseline and 2-year follow-up. The severity of NCI (normal, asymptomatic, mild, HIV dementia) was assessed according to international guidelines. Results: At baseline (400 patients, 33 with prediabetes, 39 with diabetes), in cross-sectional multivariable analyses, patients with diabetes performed significantly worse on 9 neuropsychological tests that assessed memory, executive functions, attention, psychomotor speed, language, and manual dexterity. Participants with prediabetes had worse performances compared with those who had normal glycemia in 5 tests. The longitudinal analysis of the association between glycemia status at baseline and change in cognitive performances over 2-year follow-up (n = 283) suggested that patients with diabetes also showed a slightly higher decline on 5 of the 10 tests, those involving executive functions and memory functioning. Glycemia status at baseline was not significantly associated with NCI severity in cross-sectional (p = 0.44) and longitudinal (p = 0.64) analyses.
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Neurology, American Academy of Neurology, 2015, 85 (12), pp.1065-1073. 〈10.1212/WNL.0000000000001815〉
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Soumis le : mardi 15 mars 2016 - 16:47:11
Dernière modification le : mardi 18 septembre 2018 - 16:24:01

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Carole Dufouil, Laura Richert, Rodolphe Thiebaut, Mathias Bruyand, Hélène Amieva, et al.. Diabetes and cognitive decline in a French cohort of patients infected with HIV-1. Neurology, American Academy of Neurology, 2015, 85 (12), pp.1065-1073. 〈10.1212/WNL.0000000000001815〉. 〈hal-01288876〉

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