OFSEP, a nationwide cohort of people with multiple sclerosis: Consensus minimal MRI protocol

Roxana Amélie 1 René Anxionnat 2 Jean-Paul Armspach 3 Bertrand Audoin 4, 5 Christian Barillot 6 Isabelle Berry 7 Fabrice Bonneville 8 Claire Boutet 9, 10, 11, 12 Giovanni Castelnovo 13 Frédéric Cervenansky 14 Mikael Cohen 15 Olivier Commowick 6 François Cotton 16, 17 Jérôme de Seze 18 Vincent Dousset 19 Françoise Durand-Dubief 17, 20 Gilles Edan 6, 21 Jean-Christophe Ferre 6, 22, 23 Damien Galanaud 24, 9, 12 Tristan Glattard 25 Sylvie Grand 26 Justine Guillaumont 6 Rémy Guillevin 27 Charles Guttmann 28 Salem Hannoun 25 Fabrice Heitz 29 Alexandre Krainik 30, 31 Stéphane Kremer 32 Pierre Labauge 33 Nicolas Menjot de Champfleur 34 Jean-Philippe Ranjeva 4 Jean-Amédée Roch 35 Dominique Sappey-Marinier 36, 17 Julien Savatovsky 37 Bruno Stankoff 38, 39, 9 Thomas Tourdias 19 Ayman Tourbah 40 Sandra Vukusic 41
2 ISA - Models, algorithms and geometry for computer graphics and vision
INRIA Lorraine, LORIA - Laboratoire Lorrain de Recherche en Informatique et ses Applications
6 VisAGeS - Vision, Action et Gestion d'informations en Santé
INSERM - Institut National de la Santé et de la Recherche Médicale : U746, Inria Rennes – Bretagne Atlantique , IRISA-D5 - SIGNAUX ET IMAGES NUMÉRIQUES, ROBOTIQUE
12 ARAMIS - Algorithms, models and methods for images and signals of the human brain
UPMC - Université Pierre et Marie Curie - Paris 6, Inria de Paris, ICM - Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute
14 Service Informatique et développements
CREATIS - Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé
17 RMN et optique : De la mesure au biomarqueur
CREATIS - Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé
Abstract : Multiple sclerosis (MS) is most generally considered as a severe disease with high physical and mental risks of disability. Since the end of the 1990s, several high cost long-term disease-modifying treatments provided some clinical efficiency. However, patient's follow-up was needed for the detection and the assessment of their side-effects. The “Observatoire français de la sclérose en plaques” (OFSEP) project aims to improve the clinical, biological and imaging systematic longitudinal follow-up of patients. It should increase the quality, efficiency and safety of patients’ care, with a unique opportunity of large scale, about 41,000 patients followed in 62 French centers using the European Database for Multiple Sclerosis (EDMUS) software. OFSEP is divided into three working groups (clinical, biological and imaging). The imaging working group defines standards for routine MRI follow-up in the whole cohort and contains three subgroups: acquisition, workflow, and data processing. A common and feasible brain and spinal cord acquisition protocol has been defined by the acquisition group, and accepted by the OFSEP steering and scientific committees. This protocol can be implemented in all French MRI centers. The major MRI manufacturers have agreed to provide the dedicated collection of sequences as an “OFSEP box” with every software upgrade or new MRI machine. The new OFSEP protocol will provide a unique opportunity to study a population-based collection of data from people with MS.
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Roxana Amélie, René Anxionnat, Jean-Paul Armspach, Bertrand Audoin, Christian Barillot, et al.. OFSEP, a nationwide cohort of people with multiple sclerosis: Consensus minimal MRI protocol. Journal de Neuroradiologie / Journal of Neuroradiology, Elsevier Masson, 2015, 42 (3), pp.133 - 140. ⟨10.1016/j.neurad.2014.12.001⟩. ⟨hal-01378309⟩



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