Effects of initial telomere length distribution on senescence onset and heterogeneity

Abstract : Replicative senescence, induced by telomere shortening, exhibits considerable asynchrony and heterogeneity, the origins of which remain unclear. Here, we formally study how telomere shortening mechanisms impact on senescence kinetics and define two regimes of senescence, depending on the initial telomere length variance. We provide analytical solutions to the model, highlighting a non-linear relationship between senescence onset and initial telomere length distribution. This study reveals the complexity of the collective behavior of telomeres as they shorten, leading to senescence heterogeneity.
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https://hal.inria.fr/hal-01378596
Contributor : Philippe Robert <>
Submitted on : Monday, October 10, 2016 - 2:41:50 PM
Last modification on : Tuesday, November 19, 2019 - 10:48:15 AM

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  • HAL Id : hal-01378596, version 1
  • ARXIV : 1606.06842

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Sarah Eugene, Thibault Bourgeron, Zhou Xu. Effects of initial telomere length distribution on senescence onset and heterogeneity. Journal of Theoretical Biology, Elsevier, 2017, 413, pp.8. ⟨hal-01378596⟩

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