Pan-retinal characterisation of Light Responses from Ganglion Cells in the Developing Mouse Retina

Abstract : We have investigated the ontogeny of light-driven responses in mouse retinal ganglion cells (RGCs). Using a large-scale, high-density multielectrode array, we recorded from hundreds to thousands of RGCs simultaneously at pan-retinal level, including dorsal and ventral locations. Responses to different contrasts not only revealed a complex developmental profile for ON, OFF and ON-OFF RGC types, but also unveiled differences between dorsal and ventral RGCs. At eye-opening, dorsal RGCs of all types were more responsive to light, perhaps indicating an environmental priority to nest viewing for pre-weaning pups. The developmental profile of ON and OFF RGCs exhibited antagonistic behavior, with the strongest ON responses shortly after eye-opening, followed by an increase in the strength of OFF responses later on. Further, we found that with maturation receptive field (RF) center sizes decrease, responses to light get stronger, and centers become more circular while seeing differences in all of them between RGC types. These findings show that retinal functionality is not spatially homogeneous, likely reflecting ecological requirements that favour the early development of dorsal retina, and reflecting different roles in vision in the mature animal.
Type de document :
Rapport
[Research Report] Institute of Neuroscience, Newcastle University; Institute for Adaptive and Neural Computation, University of Edinburgh; Inria, Neuromathcomp Team. 2016
Liste complète des métadonnées

Littérature citée [45 références]  Voir  Masquer  Télécharger

https://hal.inria.fr/hal-01393525
Contributeur : Daniela Pamplona <>
Soumis le : lundi 7 novembre 2016 - 16:11:52
Dernière modification le : jeudi 11 janvier 2018 - 16:35:59
Document(s) archivé(s) le : mercredi 8 février 2017 - 14:32:59

Fichier

050393.full.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

Citation

Gerrit Hilgen, Sahar Pirmoradian, Daniela Pamplona, Pierre Kornprobst, Bruno Cessac, et al.. Pan-retinal characterisation of Light Responses from Ganglion Cells in the Developing Mouse Retina . [Research Report] Institute of Neuroscience, Newcastle University; Institute for Adaptive and Neural Computation, University of Edinburgh; Inria, Neuromathcomp Team. 2016. 〈hal-01393525〉

Partager

Métriques

Consultations de la notice

335

Téléchargements de fichiers

69