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BACH2 promotes indolent clinical presentation in Waldenström macroglobulinemia

Abstract : Approximately 30% of the patients who fulfil the criteria of Waldenström's macroglobulinemia (WM) are diagnosed while asymptomatic (indolent), and will not require immediate therapy. Conversely, patients with a disease-related event will be considered for therapy. The physiopathology of these 2 groups remains unclear, and the mechanisms of progression from indolent to symptomatic WM have yet to be fully understood. Seventeen patients diagnosed with WM were included in this study, 8 asymptomatic WM (A-WM) and 9 symptomatic WM (S-WM). A differential analysis was performed on a first series of 11 patients and identified 48 genes whose expression separated samples from A-to S-WM. This gene signature was then confirmed on a second independent validation set of 6 WM. Within this expression profile, BACH2, a B-cell transcription factor known to be a tumor suppressor gene, was found to be over-expressed in A-MW relatively to S-MW. We specifically over-expressed BACH2 in a WM-related cell line and observed a significant reduction of the clonogenic activity. To the best of our knowledge, we report for the first time a specific gene expression signature that differentiates A-WM and S-WM. Within this expression profile, BACH2 was identified as a candidate gene that may help to understand better the behavior of tumor cells in indolent WM.
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https://hal.inria.fr/hal-01423307
Contributor : Guillemette Marot <>
Submitted on : Thursday, December 29, 2016 - 11:29:20 AM
Last modification on : Friday, January 22, 2021 - 1:18:04 PM
Long-term archiving on: : Tuesday, March 28, 2017 - 1:55:41 AM

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  • HAL Id : hal-01423307, version 1

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Charles Herbaux, Elisabeth Bertrand, Guillemette Marot, Christophe Roumier, Nicolas Poret, et al.. BACH2 promotes indolent clinical presentation in Waldenström macroglobulinemia. Oncotarget, Impact journals, 2016. ⟨hal-01423307⟩

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