Design, optimization and predictions of a coupled model of the cell cycle, circadian clock, DNA repair system, irinotecan metabolism and exposure control under temporal logic constraints

Abstract : In systems biology, the number of available models of cellular processes increases rapidly, but re-using models in different contexts or for different questions remains a challenging issue. In this paper, we study the coupling of different models playing a role in the mammalian cell cycle and in cancer therapies. We show how the formalization of experimental observations in temporal logic with numerical constraints can be used to compute the unknown coupling kinetics parameter values agreeing with experimental data. This constraint-based approach to computing with partial information is illustrated through the design of a complex model of the mammalian cell cycle, the circadian clock, the p53/Mdm2 DNA-damage repair system, the metabolism of irinotecan and the control of cell exposure to it. We discuss the use of this model for cancer chronotherapies and evaluate its predictive power with respect to circadian core gene knockouts .
Type de document :
Article dans une revue
Theoretical Computer Science, Elsevier, 2011, 412 (21), pp.2108--2127. 〈10.1016/j.tcs.2010.10.036〉
Liste complète des métadonnées

Littérature citée [46 références]  Voir  Masquer  Télécharger

https://hal.inria.fr/hal-01431360
Contributeur : Sylvain Soliman <>
Soumis le : mardi 10 janvier 2017 - 17:03:30
Dernière modification le : jeudi 17 mai 2018 - 12:52:03
Document(s) archivé(s) le : mardi 11 avril 2017 - 16:24:26

Fichier

DFRS11tcs.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

Citation

Elisabetta De Maria, François Fages, Aurélien Rizk, Sylvain Soliman. Design, optimization and predictions of a coupled model of the cell cycle, circadian clock, DNA repair system, irinotecan metabolism and exposure control under temporal logic constraints. Theoretical Computer Science, Elsevier, 2011, 412 (21), pp.2108--2127. 〈10.1016/j.tcs.2010.10.036〉. 〈hal-01431360〉

Partager

Métriques

Consultations de la notice

268

Téléchargements de fichiers

32