Non-invasive, in vivo monitoring of neuronal transport impairment in a mouse model of tauopathy using MEMRI

Abstract : The impairment of axonal transport by overexpression or hyperphosphorylation of tau is well documented for in vitro conditions; however, only a few studies on this phenomenon have been conducted in vivo, using invasive procedures, and with contradictory results. Here we used the non-invasive, Manganese-Enhanced Magnetic Resonance Imaging technique (MEMRI), to study for the first time a pure model of tauopathy, the JNPL3 transgenic mouse line, which overexpresses a mutated (P301L) form of the human tau protein. We show progressive impairment in neuronal transport as tauopathy advances. These findings are further supported by a significant correlation between the severity of the impairment in neuronal transport assessed by MEMRI, and the degree of abnormal tau assessed by histology. Unlike conventional techniques that focus on axonal transport measurement, MEMRI can provide a global analysis of neuronal transport, i.e. from dendrites to axons and at the macroscopic scale of fiber tracts. Neuronal transport impairment has been shown to be a key pathogenic process in Alzheimer’s disease and numerous other neurodegenerative disorders. Hence, MEMRI provides a promising set of functional biomarkers to be used during preclinical trials to facilitate the selection of new drugs aimed at restoring neuronal transport in neurodegenerative diseases.
Type de document :
Article dans une revue
NeuroImage, Elsevier, 2013, 64, pp.693 - 702. 〈10.1016/j.neuroimage.2012.08.065〉
Liste complète des métadonnées

Littérature citée [58 références]  Voir  Masquer  Télécharger

https://hal.inria.fr/hal-01439335
Contributeur : Anne Bertrand <>
Soumis le : mercredi 18 janvier 2017 - 15:21:21
Dernière modification le : jeudi 11 janvier 2018 - 06:28:02
Document(s) archivé(s) le : mercredi 19 avril 2017 - 14:46:46

Fichier

neuroimage.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

Citation

Anne Bertrand, Umer Khan, Dung M. Hoang, Dmitry S. Novikov, Pavan Krishnamurthy, et al.. Non-invasive, in vivo monitoring of neuronal transport impairment in a mouse model of tauopathy using MEMRI. NeuroImage, Elsevier, 2013, 64, pp.693 - 702. 〈10.1016/j.neuroimage.2012.08.065〉. 〈hal-01439335〉

Partager

Métriques

Consultations de la notice

247

Téléchargements de fichiers

37