This paper presents the Lean and Automate method on how to streamline and automate simultaneously the production and logistics processes in order to improve quality, reduce waste, and increase agility using Lean Six Sigma with the support of some advanced technologies. The approach is based on research which showed that for the best application of Lean Six Sigma to production and logistics, the new processes should be improved taking into account also the possible use of advanced automation. The case studies provide good practical examples of the applications and implications of advanced technology in production, with theoretically grounded insights. The findings suggest that Lean and Automate could be a key enabler of Lean Six Sigma in the manufacturing organizations.