Free and Cued Selective Reminding Test – accuracy for the differential diagnosis of Alzheimer's and neurodegenerative diseases: A large-scale biomarker-characterized monocenter cohort study (ClinAD)

Abstract : Introduction: The International Working Group recommended the Free and Cued Selective Reminding Test (FCSRT) as a sensitive detector of the amnesic syndrome of the hippocampal type in typical Alzheimer's disease (AD). But does it differentiate AD from other neurodegenerative diseases? Methods: We assessed the FCSRT and cerebrospinal fluid (CSF) AD biomarkers in 992 cases. Experts , blinded to biomarker data, attributed in 650 cases a diagnosis of typical AD, frontotemporal dementia, posterior cortical atrophy, Lewy body disease, progressive supranuclear palsy, corticobasal syndrome, primary progressive aphasias, " subjective cognitive decline, " or depression. Results: The FCSRT distinguished typical AD from all other conditions with a sensitivity of 100% and a specificity of 75%. Non-AD neurodegenerative diseases with positive AD CSF biomarkers (" atypical AD ") did not have lower FCSRT scores than those with negative biomarkers. Discussion: The FCSRT is a reliable tool for diagnosing typical AD among various neurodegener-ative diseases. At an individual level, however, its specificity is not absolute. Our findings also widen the spectrum of atypical AD to multiple neurodegenerative conditions.
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Stéphane Epelbaum, Marc Teichmann, Dalila Samri, Marcel Nogueira, Harald Hampel, et al.. Free and Cued Selective Reminding Test – accuracy for the differential diagnosis of Alzheimer's and neurodegenerative diseases: A large-scale biomarker-characterized monocenter cohort study (ClinAD). Alzheimer's and Dementia, Elsevier, 2017, 13 (8), pp.913 - 923. ⟨10.1016/j.jalz.2016.12.014⟩. ⟨hal-01672862⟩

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