Skip to Main content Skip to Navigation
Journal articles

A comparison of three fiber tract delineation methods and their impact on white matter analysis

Abstract : Diffusion magnetic resonance imaging (dMRI) is an important method for studying white matter connectivity in the brain in vivo in both healthy and clinical populations. Improvements in dMRI tractography algorithms, which reconstruct macroscopic three-dimensional white matter fiber pathways, have allowed for methodological advances in the study of white matter; however, insufficient attention has been paid to comparing post-tractography methods that extract white matter fiber tracts of interest from whole-brain tractography. Here we conduct a comparison of three representative and conceptually distinct approaches to fiber tract delineation: 1) a manual multiple region of interest-based approach, 2) an atlas-based approach, and 3) a groupwise fiber clustering approach, by employing methods that exemplify these approaches to delineate the arcuate fasciculus, the middle longitudinal fasciculus, and the uncinate fasciculus in 10 healthy male subjects. We enable qualitative comparisons across methods, conduct quantitative evaluations
Document type :
Journal articles
Complete list of metadatas
Contributor : Demian Wassermann <>
Submitted on : Wednesday, December 9, 2020 - 4:29:57 PM
Last modification on : Wednesday, December 9, 2020 - 5:18:19 PM


Publisher files allowed on an open archive



Valerie Sydnor, Ana María Rivas-Grajales, Amanda Lyall, Fan Zhang, Sylvain Bouix, et al.. A comparison of three fiber tract delineation methods and their impact on white matter analysis. NeuroImage, Elsevier, 2018, 178, pp.318-331. ⟨10.1016/j.neuroimage.2018.05.044⟩. ⟨hal-01807178⟩



Record views


Files downloads