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Attenuation correction synthesis for hybrid PET-MR scanners: Application to brain studies

Ninon Burgos 1 M. J. Cardoso K. Thielemans M. Modat S. Pedemonte J. Dickson A. Barnes R. Ahmed C. J. Mahoney J. M. Schott J. S. Duncan 2, 3, 4 D. Atkinson 1 S. R. Arridge B. F. Hutton S. Ourselin 1
1 CMIC - Centre for Medical Image Computing
2 Clinical Sciences Centre
3 Epilepsy Society
4 Department of Clinical and Experimental Epilepsy
Abstract : Attenuation correction is an essential requirement for quantification of positron emission tomography (PET) data. In PET/CT acquisition systems, attenuation maps are derived from computed tomography (CT) images. However, in hybrid PET/MR scanners, magnetic resonance imaging (MRI) images do not directly provide a patient-specific attenuation map. The aim of the proposed work is to improve attenuation correction for PET/MR scanners by generating synthetic CTs and attenuation maps. The synthetic images are generated through a multi-atlas information propagation scheme, locally matching the MRI-derived patient's morphology to a database of MRI/CT pairs, using a local image similarity measure. Results show significant improvements in CT synthesis and PET reconstruction accuracy when compared to a segmentation method using an ultrashort-echo-time MRI sequence and to a simplified atlas-based method.
Keywords : Attenuation positron emission tomography magnetic resonance imaging medical image processing biomedical MRI image matching neurophysiology image reconstruction Image synthesis Computed tomography Attenuation correction Bones computerised tomography positron emission tomography/magnetic resonance (PET/MR) Databases 0 Accuracy attenuation correction improvement attenuation correction synthesis biomedical equipment brain study application computed tomography image CT synthesis data acquisition database of MRI-CT pair matching hybrid PET-MR scanner local image similarity measure MRI image MRI-derived patient morphology matching multi-atlas information propagation scheme patient-specific attenuation map PET reconstruction accuracy PET-CT acquisition system positron emission tomography data quantification segmentation method simplified atlas-based method synthetic attenuation map generation synthetic CT image generation ultrashort-echo-time MRI sequence visual databases brain
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https://hal.inria.fr/hal-01827217
Contributor : Ninon Burgos <>
Submitted on : Sunday, July 1, 2018 - 10:43:02 PM
Last modification on : Friday, December 4, 2020 - 2:30:01 PM

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Ninon Burgos, M. J. Cardoso, K. Thielemans, M. Modat, S. Pedemonte, et al.. Attenuation correction synthesis for hybrid PET-MR scanners: Application to brain studies. IEEE Transactions on Medical Imaging, Institute of Electrical and Electronics Engineers, 2014, 33 (12), pp.2332--2341. ⟨10.1109/TMI.2014.2340135⟩. ⟨hal-01827217⟩

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