Advances in Analyzing Virus-Induced Alterations of Host Cell Splicing

Abstract : Alteration of host cell splicing is a common feature of many viral infections which is underappreciated because of the complexity and technical difficulty of studying alternative splicing (AS) regulation. Recent advances in RNA sequencing technologies revealed that up to several hundreds of host genes can show altered mRNA splicing upon viral infection. The observed changes in AS events can be either a direct consequence of viral manipulation of the host splicing machinery or result indirectly from the virus-induced innate immune response or cellular damage. Analysis at a higher resolution with single-cell RNAseq, and at a higher scale with the integration of multiple omics data sets in a systems biology perspective, will be needed to further comprehend this complex facet of virus-host interactions.
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Trends in Microbiology, Elsevier, 2018, pp.1-53. 〈10.1016/j.tim.2018.11.004〉
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https://hal.inria.fr/hal-01964983
Contributeur : Marie-France Sagot <>
Soumis le : lundi 24 décembre 2018 - 15:02:54
Dernière modification le : jeudi 7 février 2019 - 17:11:49

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Usama Ashraf, Clara Benoit-Pilven, Vincent Lacroix, Vincent Navratil, Nadia Naffakh. Advances in Analyzing Virus-Induced Alterations of Host Cell Splicing. Trends in Microbiology, Elsevier, 2018, pp.1-53. 〈10.1016/j.tim.2018.11.004〉. 〈hal-01964983〉

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