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G protein-coupled receptor-mediated calcium signaling in astrocytes

Maurizio de Pittà 1 Eshel Ben-Jacob 2 Hugues Berry 3, 4, 5
3 BEAGLE - Artificial Evolution and Computational Biology
LBBE - Laboratoire de Biométrie et Biologie Evolutive - UMR 5558, Inria Grenoble - Rhône-Alpes, LIRIS - Laboratoire d'InfoRmatique en Image et Systèmes d'information
Abstract : Astrocytes express a large variety of G protein-coupled receptors (GPCRs) which mediate the transduction of extracellular signals into intracellular calcium responses. This transduc-tion is provided by a complex network of biochemical reactions which mobilizes a wealth of possible calcium-mobilizing second messenger molecules. Inositol 1,4,5-trisphosphate is probably the best known of these molecules whose enzymes for its production and degradation are nonetheless calcium-dependent. We present a biophysical modeling approach based on the assumption of Michaelis-Menten enzyme kinetics, to effectively describe GPCR-mediated astrocytic calcium signals. Our model is then used to study different mechanisms at play in stimulus encoding by shape and frequency of calcium oscillations in astrocytes.
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Submitted on : Sunday, January 27, 2019 - 10:30:28 PM
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Maurizio de Pittà, Eshel Ben-Jacob, Hugues Berry. G protein-coupled receptor-mediated calcium signaling in astrocytes. Maurizio De Pittà; Hugues Berry. Computational Glioscience, Springer, pp.115-150, 2019, Springer Series in Computational Neuroscience, 978-3-030-00817-8. ⟨10.1007/978-3-030-00817-8_5⟩. ⟨hal-01995850⟩



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