Skip to Main content Skip to Navigation
Book sections

Astrocyte networks and intercellular calcium propagation

Jules Lallouette 1, 2 Maurizio de Pittà 3 Hugues Berry 2, 1, 4
2 BEAGLE - Artificial Evolution and Computational Biology
LIRIS - Laboratoire d'InfoRmatique en Image et Systèmes d'information, Inria Grenoble - Rhône-Alpes, LBBE - Laboratoire de Biométrie et Biologie Evolutive - UMR 5558
Abstract : Astrocytes organize in complex networks through connections by gap junction channels that are regulated by extra-and intracellular signals. Calcium signals generated in individual cells, can propagate across these networks in the form of intercellular calcium waves, mediated by diffusion of second messengers molecules such as inositol 1,4,5-trisphosphate. The mechanisms underpinning the large variety of spatiotemporal patterns of propagation of astrocytic calcium waves however remain a matter of investigation. In the last decade, awareness has grown on the morphological diversity of astrocytes as well as their connections in networks, which seem dependent on the brain area, developmental stage, and the ultra-structure of the associated neuropile. It is speculated that this diversity underpins an equal functional variety but the current experimental techniques are limited in supporting this hypothesis because they do not allow to resolve the exact connectivity of astrocyte networks in the brain. With this aim we present a general framework to model intercellular calcium wave propagation in astrocyte networks and use it to specifically investigate how different network topologies could influence shape, frequency and propagation of these waves.
Complete list of metadata

Cited literature [106 references]  Display  Hide  Download
Contributor : Hugues Berry Connect in order to contact the contributor
Submitted on : Sunday, January 27, 2019 - 10:34:35 PM
Last modification on : Tuesday, July 20, 2021 - 5:20:04 PM
Long-term archiving on: : Sunday, April 28, 2019 - 12:31:15 PM


Files produced by the author(s)



Jules Lallouette, Maurizio de Pittà, Hugues Berry. Astrocyte networks and intercellular calcium propagation. Maurizio De Pittà; Hugues Berry. Computational Glioscience, pp.177-210, 2019, Springer Series in Computational Neuroscience, 978-3-030-00817-8. ⟨10.1007/978-3-030-00817-8_7⟩. ⟨hal-01995852⟩



Les métriques sont temporairement indisponibles