This paper presents a new intelligent Human-Computer Interaction (HCI) device for Assistive Technology. The developed device can be used as a mouse or as a gamepad, moving a part of the human body, typically the head, for hands-free computer access tasks. The state-of-the-art hardware uses an Advanced RISC Machine 32-bit microcontroller and a microelectromechanical 9-degree motion sensor, including a System-in-Package (SiP) accelerometer, gyroscope and magnetometer. The hardware/software device with a human-in-the-loop controller can be identified as a Cyber-Physical intelligent system to be incorporated in the “Industry 4.0” trend. Results reveal that the embedded controller of the HID device allows the improvement of the user’s performance, decreasing the effort and the execution time of the hands-free computer tasks.