We provide continuous-discrete observers for a large class of time-varying linear systems where the inputs and outputs have sampling and delays, and where the systems and outputs contain uncertainties. We allow the delays in the output and input to differ and to be arbitrarily long. We use the observers to design controls that ensure input-to-state stability, under delays and sampling. The observers and controls have no distributed terms. We illustrate our work in two examples including a DC motor model.