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Adaptation by copy number variation increases insecticide resistance in the fall armyworm

Sylvie Gimenez 1 Heba Abdelgaffar 2 Gaelle Le Goff 3 Frédérique Hilliou 3 Carlos Blanco 4 Sabine Hänniger 5 Anthony Bretaudeau 6, 7 Fabrice Legeai 6, 8 Nicolas Nègre 1 Juan Luis Jurat-Fuentes 2 Emmanuelle d'Alençon 1 Kiwoong Nam 1, *
* Corresponding author
1 DGIMI - Diversité, Génomes & Interactions Microorganismes - Insectes [Montpellier]
2 The University of Tennessee [Knoxville]
3 ISA - Institut Sophia Agrobiotech
4 USDA - United States Department of Agriculture
5 Max Planck Institute for Chemical Ecology
6 IGEPP - Institut de Génétique, Environnement et Protection des Plantes
7 Plateforme bioinformatique GenOuest [Rennes]
UR1 - Université de Rennes 1, Plateforme Génomique Santé Biogenouest®, Inria Rennes – Bretagne Atlantique , IRISA-D7 - GESTION DES DONNÉES ET DE LA CONNAISSANCE
8 GenScale - Scalable, Optimized and Parallel Algorithms for Genomics
Inria Rennes – Bretagne Atlantique , IRISA-D7 - GESTION DES DONNÉES ET DE LA CONNAISSANCE
Abstract : Understanding the genetic basis of insecticide resistance is a key topic in agricultural ecology. The adaptive evolution of multi-copy detoxification genes has been interpreted as a cause of insecticide resistance, yet the same pattern can also be generated by the adaptation to host-plant defense toxins. In this study, we tested in the fall armyworm, Spodoptera frugiperda (Lepidoptera: Noctuidae), if adaptation by copy number variation caused insecticide resistance in two geographically distinct populations with different levels of resistance and the two host-plant strains. We observed a significant allelic differentiation of genomic copy number variations between the two geographic populations, but not between host-plant strains. A locus with positively selected copy number variation included a CYP gene cluster. Toxicological tests supported a central role for CYP enzymes in deltamethrin resistance. Our results indicate that copy number variation of detoxification genes might be responsible for insecticide resistance in fall armyworm and that evolutionary forces causing insecticide resistance could be independent of host-plant adaptation.
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https://hal.inria.fr/hal-03065279
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Submitted on : Friday, May 28, 2021 - 11:22:27 AM
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UR1-UFR-ISTIC | BA | UNIV-MONTPELLIER | UNIV-COTEDAZUR | UNIV-RENNES | DGIMI | INRAE | INRAEOCCITANIEMONTPELLIER | UR1-MATH-NUM | UR1-ENV | UR1-MATH-STIC | UNIV-RENNES1 | CNRS | INRIA | INSA-RENNES | IRISA | UNAM | BIOSIT | UR1-UFR-SVE | CENTRALESUPELEC | INSTITUT-SOPHIA-AGROBIOTECH

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Sylvie Gimenez, Heba Abdelgaffar, Gaelle Le Goff, Frédérique Hilliou, Carlos Blanco, et al.. Adaptation by copy number variation increases insecticide resistance in the fall armyworm. Communications Biology, Nature Publishing Group, 2020, 3 (1), pp.1-10. ⟨10.1038/s42003-020-01382-6⟩. ⟨hal-03065279⟩

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