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Boosting the analysis of protein interfaces with Multiple Interface String Alignment: illustration on the spikes of coronaviruses

Abstract : We introduce Multiple Interface String Alignment (MISA), a visualization tool to display coherently various sequence and structure based statistics at protein-protein interfaces (SSE elements, buried surface area, ΔASA, B factor values, etc). The amino-acids supporting these annotations are obtained from Voronoi interface models. The benefit of MISA is to collate annotated sequences of (homologous) chains found in different biological contexts i.e. bound with different partners or unbound. The aggregated views MISA/SSE, MISA/BSA, MISA/Δ ASAetc make it trivial to identify commonalities and differences between chains, to infer key interface residues, and to understand where conformational changes occur upon binding. As such, they should prove of key relevance for knowledge based annotations of protein databases such as the Protein Data Bank.
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Preprints, Working Papers, ...
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https://hal.inria.fr/hal-03139494
Contributor : Frederic Cazals Connect in order to contact the contributor
Submitted on : Friday, February 12, 2021 - 9:23:37 AM
Last modification on : Thursday, January 20, 2022 - 5:27:02 PM

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Stéphane Bereux, Bernard Delmas, Frédéric Cazals. Boosting the analysis of protein interfaces with Multiple Interface String Alignment: illustration on the spikes of coronaviruses. 2020. ⟨hal-03139494⟩

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