A new molecular classification to drive precision treatment strategies in primary Sjögren’s syndrome

Perrine Soret; Christelle Le Dantec; Emiko Desvaux; Nathan Foulquier; Bastien Chassagnol; Sandra Hubert; Christophe Jamin; Guillermo Barturen; Guillaume Desachy; Valérie Devauchelle-Pensec; Cheïma Boudjeniba; Divi Cornec; Alain Saraux; Sandrine Jousse-Joulin; Nuria Barbarroja; Ignasi Rodríguez-Pintó; Ellen de Langhe; Lorenzo Beretta; Carlo Chizzolini; László Kovács; Torsten Witte; Eléonore Bettacchioli; Anne Buttgereit; Zuzanna Makowska; Ralf Lesche; Maria Orietta Borghi; Javier Martin; Sophie Courtade-Gaiani; Laura Xuereb; Mickaël Guedj; Philippe Moingeon; Marta Alarcón-Riquelme; Laurence Laigle; Jacques-Olivier Pers; Barbara Vigone; Bernard Lauwerys; Anne-Lise Maudoux; Carlos Vasconcelos; Ana Tavares; Raquel Faria; Mariana Brandão; Ana Campar; António Marinho; Fátima Farinha; Isabel Almeida; Miguel Angel Gonzalez-Gay Mantecón; Ricardo Blanco Alonso; Alfonso Corrales Martínez; Ricard Cervera; Gerard Espinosa; Rik Lories; Nicolas Hunzelmann; Doreen Belz; Niklas Baerlecken; Georg Stummvoll; Michael Zauner; Michaela Lehner; Eduardo Collantes; Rafaela Ortega-Castro; Ma Angeles Aguirre-Zamorano; Alejandro Escudero-Contreras; Ma Carmen Castro-Villegas; Yolanda Jiménez Gómez; Norberto Ortego; María Concepción Fernández Roldán; Enrique Raya; Inmaculada Jiménez Moleón; Enrique de Ramon; Isabel Díaz Quintero; Pier Luigi Meroni; Maria Gerosa; Tommaso Schioppo; Carolina Artusi; Aleksandra Zuber; Donatienne Wynar; Attila Balog; Magdolna Deák; Márta Bocskai; Sonja Dulic; Gabriella Kádár; Falk Hiepe; Silvia Thiel; Manuel Rodriguez Maresca; Antonio López-Berrio; Rocío Aguilar-Quesada; Héctor Navarro-Linares; Yiannis Ioannou; Chris Chamberlain; Jacqueline Marovac; Marta Alarcón Riquelme; Tania Gomes Anjos; Concepción Marañón; Lucas Le Lann; Quentin Simon; Bénédicte Rouvière; Nieves Varela; Brian Muchmore; Aleksandra Dufour; Montserrat Alvarez; Jonathan Cremer; Chary Lopez-Pedrera; Velia Gerl; Laleh Khodadadi; Qingyu Cheng; Aurélie de Groof; Julie Ducreux; Elena Trombetta; Tianlu Li; Damiana Alvarez-Errico; Katja Kniesch; Nancy Azevedo; Esmeralda Neves; Sambasiva Rao; Pierre-Emmanuel Jouve

doi:10.1038/s41467-021-23472-7

Journal Articles Nature Communications Year : 2021

A new molecular classification to drive precision treatment strategies in primary Sjögren’s syndrome

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Perrine Soret

Function : Author

Institut de Recherches Internationales Servier [Suresnes]

Christelle Le Dantec

Function : Author

Lymphocytes B, Autoimmunité et Immunothérapies

Emiko Desvaux

Function : Author

Institut de Recherches Internationales Servier [Suresnes]

Lymphocytes B, Autoimmunité et Immunothérapies

Nathan Foulquier

Function : Author

Lymphocytes B, Autoimmunité et Immunothérapies

Bastien Chassagnol

Function : Author

Institut de Recherches Internationales Servier [Suresnes]

Sandra Hubert

Function : Author

Institut de Recherches Internationales Servier [Suresnes]

Christophe Jamin

Function : Author
PersonId : 2136
IdHAL : christophe-jamin
ORCID : 0000-0002-9494-3223
IdRef : 116289511

Lymphocytes B, Autoimmunité et Immunothérapies

Guillermo Barturen

Function : Author

Centre for Genomics and Oncological Reearch (GENYO)

Guillaume Desachy

Function : Author

Institut de Recherches Internationales Servier [Suresnes]

Valérie Devauchelle-Pensec

Function : Author
PersonId : 766858
ORCID : 0000-0003-0432-825X

Lymphocytes B, Autoimmunité et Immunothérapies

CHRU Brest - Service de Rhumatologie

Cheïma Boudjeniba

Function : Author

Institut de Recherches Internationales Servier [Suresnes]

Divi Cornec

Function : Author
PersonId : 766860
ORCID : 0000-0002-9159-702X

Lymphocytes B, Autoimmunité et Immunothérapies

CHRU Brest - Service de Rhumatologie

Alain Saraux

Function : Author
PersonId : 762362
ORCID : 0000-0002-8454-7067

Lymphocytes B, Autoimmunité et Immunothérapies

CHRU Brest - Service de Rhumatologie

Sandrine Jousse-Joulin

Function : Author
PersonId : 766854
ORCID : 0000-0002-5479-5887

Lymphocytes B, Autoimmunité et Immunothérapies

CHRU Brest - Service de Rhumatologie

Nuria Barbarroja

Function : Author

Instituto Maimonides de Investigación Biomédica de Cordoba

Ignasi Rodríguez-Pintó

Function : Author

Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)

Ellen de Langhe

Function : Author

Catholic University of Leuven = Katholieke Universiteit Leuven

Lorenzo Beretta

Function : Author

Maggiore Hospital, IRCCS Foundation, Milano

Carlo Chizzolini

Function : Author
PersonId : 767598
ORCID : 0000-0003-4849-6335

Department of Pathology and Immunology [Geneva, Switzerland]

László Kovács

Function : Author

University of Szeged [Szeged]

Torsten Witte

Function : Author

Clinic for Immunology and Rhematology, Hannover Medical School, Hanover, Germany

Eléonore Bettacchioli

Function : Author

Hôpital Morvan - CHRU de Brest

Anne Buttgereit

Function : Author

Pharmaceuticals Division Bayer Pharma Aktiengesellschaft

Zuzanna Makowska

Function : Author

Pharmaceuticals Division Bayer Pharma Aktiengesellschaft

Ralf Lesche

Function : Author

Pharmaceuticals Division Bayer Pharma Aktiengesellschaft

Maria Orietta Borghi

Function : Author

Università degli Studi di Milano = University of Milan

Javier Martin

Function : Author

Instituto de Parasitología y Biomedicina “López-Neyra”

Sophie Courtade-Gaiani

Function : Author

Institut de Recherches Internationales Servier [Suresnes]

Laura Xuereb

Function : Author

Institut de Recherches Internationales Servier [Suresnes]

Mickaël Guedj

Function : Author

Institut de Recherches Internationales Servier [Suresnes]

Philippe Moingeon

Function : Author

Institut de Recherches Internationales Servier [Suresnes]

Marta Alarcón-Riquelme

Function : Author

Universidad de Granada = University of Granada

Laurence Laigle

Function : Author

Institut de Recherches Internationales Servier [Suresnes]

Jacques-Olivier Pers

Function : Author
PersonId : 753610
IdHAL : jacques-olivier-pers
ORCID : 0000-0001-7287-5541
IdRef : 068262159

Lymphocytes B, Autoimmunité et Immunothérapies

Hôpital Morvan - CHRU de Brest

Barbara Vigone

Function : Author

Università degli Studi di Milano = University of Milan

Bernard Lauwerys

Function : Author

Anne-Lise Maudoux

Function : Author

Carlos Vasconcelos

Function : Author

Ana Tavares

Function : Author

Raquel Faria

Function : Author

Mariana Brandão

Function : Author

Ana Campar

Function : Author

António Marinho

Function : Author

Fátima Farinha

Function : Author

Isabel Almeida

Function : Author

Miguel Angel Gonzalez-Gay Mantecón

Function : Author

Ricardo Blanco Alonso

Function : Author

Alfonso Corrales Martínez

Function : Author

Ricard Cervera

Function : Author

Gerard Espinosa

Function : Author

Rik Lories

Function : Author

Nicolas Hunzelmann

Function : Author

Doreen Belz

Function : Author

Niklas Baerlecken

Function : Author

Georg Stummvoll

Function : Author

Michael Zauner

Function : Author

Michaela Lehner

Function : Author

Eduardo Collantes

Function : Author

Rafaela Ortega-Castro

Function : Author

Ma Angeles Aguirre-Zamorano

Function : Author

Alejandro Escudero-Contreras

Function : Author

Ma Carmen Castro-Villegas

Function : Author

Yolanda Jiménez Gómez

Function : Author

Norberto Ortego

Function : Author

María Concepción Fernández Roldán

Function : Author

Enrique Raya

Function : Author

Inmaculada Jiménez Moleón

Function : Author

Enrique de Ramon

Function : Author

Isabel Díaz Quintero

Function : Author

Pier Luigi Meroni

Function : Author

Maria Gerosa

Function : Author

Tommaso Schioppo

Function : Author

Carolina Artusi

Function : Author

Aleksandra Zuber

Function : Author

Donatienne Wynar

Function : Author

Attila Balog

Function : Author

Magdolna Deák

Function : Author

Márta Bocskai

Function : Author

Sonja Dulic

Function : Author

Gabriella Kádár

Function : Author

Falk Hiepe

Function : Author

Silvia Thiel

Function : Author

Manuel Rodriguez Maresca

Function : Author

Antonio López-Berrio

Function : Author

Rocío Aguilar-Quesada

Function : Author

Héctor Navarro-Linares

Function : Author

Yiannis Ioannou

Function : Author

Chris Chamberlain

Function : Author

Jacqueline Marovac

Function : Author

Marta Alarcón Riquelme

Function : Author

Tania Gomes Anjos

Function : Author

Concepción Marañón

Function : Author

Lucas Le Lann

Function : Author

Quentin Simon

Function : Author

Bénédicte Rouvière

Function : Author

Nieves Varela

Function : Author

Brian Muchmore

Function : Author

Aleksandra Dufour

Function : Author

Montserrat Alvarez

Function : Author

Jonathan Cremer

Function : Author

Chary Lopez-Pedrera

Function : Author

Velia Gerl

Function : Author

Laleh Khodadadi

Function : Author

Qingyu Cheng

Function : Author

Aurélie de Groof

Function : Author

Julie Ducreux

Function : Author

Elena Trombetta

Function : Author

Tianlu Li

Function : Author

Damiana Alvarez-Errico

Function : Author

Katja Kniesch

Function : Author

Nancy Azevedo

Function : Author

Esmeralda Neves

Function : Author

Sambasiva Rao

Function : Author

Pierre-Emmanuel Jouve

Function : Author

Abstract

Abstract There is currently no approved treatment for primary Sjögren’s syndrome, a disease that primarily affects adult women. The difficulty in developing effective therapies is -in part- because of the heterogeneity in the clinical manifestation and pathophysiology of the disease. Finding common molecular signatures among patient subgroups could improve our understanding of disease etiology, and facilitate the development of targeted therapeutics. Here, we report, in a cross-sectional cohort, a molecular classification scheme for Sjögren’s syndrome patients based on the multi-omic profiling of whole blood samples from a European cohort of over 300 patients, and a similar number of age and gender-matched healthy volunteers. Using transcriptomic, genomic, epigenetic, cytokine expression and flow cytometry data, combined with clinical parameters, we identify four groups of patients with distinct patterns of immune dysregulation. The biomarkers we identify can be used by machine learning classifiers to sort future patients into subgroups, allowing the re-evaluation of response to treatments in clinical trials.

Keywords

cell cycle, chronic lymphocytic leukemia, liquid chromatography-tandem mass spectrometry, splicing

Domains

Immunology

Geneviève Michel : Connect in order to contact the contributor

https://hal.univ-brest.fr/hal-03301637

Submitted on : Tuesday, July 27, 2021-3:47:45 PM

Last modification on : Tuesday, April 16, 2024-1:02:16 PM

Dates and versions

hal-03301637 , version 1 (27-07-2021)

Identifiers

HAL Id : hal-03301637 , version 1
DOI : 10.1038/s41467-021-23472-7
PUBMED : 34112769
PUBMEDCENTRAL : PMC8192578

Cite

Perrine Soret, Christelle Le Dantec, Emiko Desvaux, Nathan Foulquier, Bastien Chassagnol, et al.. A new molecular classification to drive precision treatment strategies in primary Sjögren’s syndrome: Identification of altered cell signaling pathways using proteomic profiling in stable and progressive chronic lymphocytic leukemia.. Nature Communications, 2021, 12 (1), pp.3523. ⟨10.1038/s41467-021-23472-7⟩. ⟨hal-03301637⟩

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A new molecular classification to drive precision treatment strategies in primary Sjögren’s syndrome

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