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A Framework for Fixed Priority Periodic Scheduling Synthesis from Synchronous Data-flow Graphs

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Abstract

Unlabelled - Medicinally active compounds in the flavonoid class of phytochemicals are being studied for antiviral action against various DNA and RNA viruses. Quercetin is a flavonoid present in a wide range of foods, including fruits and vegetables. It is said to be efficient against a wide range of viruses. This research investigated the usefulness of Quercetin against Hepatitis C virus, Dengue type 2 virus, Ebola virus, and Influenza A using computational models. A molecular docking study using the online tool PockDrug was accomplished to identify the best binding sites between Quercetin and PubChem-based receptors. Network-pharmacological assay to opt to verify function-specific gene-compound interactions using STITCH, STRING, GSEA, Cytoscape plugin cytoHubba. Quercetin explored tremendous binding affinity against NS5A protein for HCV with a docking score of - 6.268 kcal/mol, NS5 for DENV-2 with a docking score of - 5.393 kcal/mol, VP35 protein for EBOV with a docking score of - 4.524 kcal/mol, and NP protein for IAV with a docking score of - 6.954 kcal/mol. In the network-pharmacology study, out of 39 hub genes, 38 genes have been found to interact with Quercetin and the top interconnected nodes in the protein-protein network were (based on the degree of interaction with other nodes) and Negative binding energies were noticed in Quercetin-receptor interaction. Results demonstrate that Quercetin could be a potential antiviral agent against these viral diseases with further study in models. Supplementary information - The online version contains supplementary material available at 10.1007/s40203-022-00132-2.
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Dates and versions

hal-03488217 , version 1 (17-12-2021)

Identifiers

  • HAL Id : hal-03488217 , version 1

Cite

Hai Nam Tran, Alexandre Honorat, Shuvra S Bhattacharyya, Jean-Pierre Talpin, Thierry Gautier, et al.. A Framework for Fixed Priority Periodic Scheduling Synthesis from Synchronous Data-flow Graphs. SAMOS XXI 2021 - 21st International Conference on embedded computer Systems: Architectures, MOdeling and Simulation, Jul 2021, Virtual, France. pp.1-12. ⟨hal-03488217⟩
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