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Efficiently sparse listing of classes of optimal cophylogeny reconciliations

Abstract : Background : Cophylogeny reconciliation is a powerful method for analyzing host-parasite (or host-symbiont) co-evolution. It models co-evolution as an optimization problem where the set of all optimal solutions may represent different biological scenarios which thus need to be analyzed separately. Despite the significant research done in the area, few approaches have addressed the problem of helping the biologist deal with the often huge space of optimal solutions. Results : In this paper, we propose a new approach to tackle this problem. We introduce three different criteria under which two solutions may be considered biologically equivalent, and then we propose polynomial-delay algorithms that enumerate only one representative per equivalence class (without listing all the solutions). Conclusions : Our results are of both theoretical and practical importance. Indeed, as shown by the experiments, we are able to significantly reduce the space of optimal solutions while still maintaining important biological information about the whole space.
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Contributor : Marie-France Sagot Connect in order to contact the contributor
Submitted on : Wednesday, February 16, 2022 - 7:57:25 AM
Last modification on : Tuesday, May 17, 2022 - 2:50:02 PM
Long-term archiving on: : Tuesday, May 17, 2022 - 6:10:24 PM


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Yishu Wang, Arnaud Mary, Marie-France Sagot, Blerina Sinaimeri. Efficiently sparse listing of classes of optimal cophylogeny reconciliations. Algorithms for Molecular Biology, BioMed Central, 2022, 17 (1), pp.1-16. ⟨10.1186/s13015-022-00206-y⟩. ⟨hal-03576371⟩



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