Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL), the most frequent cerebral small artery disease is caused by stereotyped mutations of the NOTCH3 gene. The multifaceted clinical presentation of this disorder can be assessed using various measures. We used a bayesian mixed effect model(Leaspy) to model the multivariate disease progression and explore the spatiotemporal relationships between these measures. We were also able to identify different groups of individual evolution according to the time shift and acceleration rate by taking into account the gender, education level, smoking, hypertension and the mutation's position.