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On the estimation of the pseudo-stoichiometric matrix for mass balance modeling of biotechnological processes

Olivier Bernard 1 Georges Bastin
1 COMORE - Modeling and control of renewable resources
LOV - Laboratoire d'océanographie de Villefranche, CRISAM - Inria Sophia Antipolis - Méditerranée
Abstract : In this paper we propose a methodology to determine the structure of the pseudo-stoichiometric coefficient matrix in a mass balance based model. validate the The first step consists in estimating the number of reactions that must be taken into account to represent the main mass transfer within the bioreactor. This provides the dimension of . Then we discuss the identifiability of the components of and we propose a method to estimate their values. Finally we present a method to select among a set of possible reaction networks those which are in agreement with the available measurements. its zeros These methods are illustrated with real data of the growth of filamentous fungi Pycnoporus cinabarinnus, and with a process of lipase production from olive oil by Candida rugosa.
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Submitted on : Tuesday, May 23, 2006 - 6:09:43 PM
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  • HAL Id : inria-00071601, version 1

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Olivier Bernard, Georges Bastin. On the estimation of the pseudo-stoichiometric matrix for mass balance modeling of biotechnological processes. RR-4977, INRIA. 2003. ⟨inria-00071601⟩

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