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Automatic Alignment of Histological Sections for 3D Reconstruction and Analysis

Abstract : In this report, we present a new method of aligning histological sections. First a displacement field between the two images is computed by block matching. Then we estimate a rigid transformation based on the field. The process is integrated within a multi-scale scheme. We carefully study the problem of robustness and we propose several ideas to deal with inter-sect- ion intensity differences and background artifacts. We demonstrate experimenta- lly that we can reach a sub-voxel accuracy and we show some results on histological sections of a rat's brain and an endometrical adenocarcinoma.
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Submitted on : Wednesday, May 24, 2006 - 11:49:10 AM
Last modification on : Friday, February 4, 2022 - 3:14:40 AM
Long-term archiving on: : Sunday, April 4, 2010 - 9:16:48 PM


  • HAL Id : inria-00073084, version 1



Sébastien Ourselin, Alexis Roche, Gérard Subsol, Xavier Pennec, Christophe Sattonnet. Automatic Alignment of Histological Sections for 3D Reconstruction and Analysis. RR-3595, INRIA. 1998. ⟨inria-00073084⟩



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