Automatic Alignment of Histological Sections for 3D Reconstruction and Analysis

Abstract : In this report, we present a new method of aligning histological sections. First a displacement field between the two images is computed by block matching. Then we estimate a rigid transformation based on the field. The process is integrated within a multi-scale scheme. We carefully study the problem of robustness and we propose several ideas to deal with inter-sect- ion intensity differences and background artifacts. We demonstrate experimenta- lly that we can reach a sub-voxel accuracy and we show some results on histological sections of a rat's brain and an endometrical adenocarcinoma.
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Rapport
RR-3595, INRIA. 1998
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Sébastien Ourselin, Alexis Roche, Gérard Subsol, Xavier Pennec, Christophe Sattonnet. Automatic Alignment of Histological Sections for 3D Reconstruction and Analysis. RR-3595, INRIA. 1998. 〈inria-00073084〉

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