Comparative genomics of protoploid Saccharomycetaceae.

Jean-Luc Souciet 1, * Bernard Dujon 2 Claude Gaillardin 3 Mark Johnston 4 Philippe V Baret 5 Paul Cliften 6 David James Sherman 7, 8 Jean Weissenbach 9, 10 Eric Westhof 11 Patrick Wincker 10, 12 Claire Jubin 10 Julie Poulain 10 Valerie Barbe 9, 10 Béatrice Ségurens 10 Francois Artiguenave 10 Veronique Anthouard 9, 10 Benoit Vacherie 10 Marie-Eve Val 10 Robert S Fulton 4 Patrick Minx 4 Richard Wilson 4 Pascal Durrens 7, 8 Geraldine Jean 8 Christian Marck 13 Tiphaine Martin 7, 14 Macha Nikolski 7, 8 Thomas Rolland 2 Marie-Line Seret 5 Serge Casaregola 3 Laurence Despons 15 Cecile Fairhead 2 Gilles Fischer 2 Ingrid Lafontaine 2 Veronique Leh 1 Marc Lemaire 16 Jacky De Montigny 1 Cecile Neuveglise 3 Agnes Thierry 2 Isabelle Blanc-Lenfle 3 Claudine Bleykasten 1 Julie Diffels 5 Emilie Fritsch 1 Lionel Frangeul 17 Adrien Goeffon 7, 8 Nicolas Jauniaux 1 Rym Kachouri-Lafond 11 Celia Payen 2 Serge Potier 1 Lenka Pribylova 1, 18 Christophe Ozanne 3 Guy-Franck Richard 2 Christine Sacerdot 2 Marie-Laure Straub 1 Emmanuel Talla 19
* Auteur correspondant
1 GMGM - Génétique moléculaire, génomique, microbiologie
2 Génétique Moléculaire des Levures
3 MGM - Microbiologie et Génétique Moléculaire
4 Department of Genetics [Saint-Louis]
5 UCL - Université Catholique de Louvain
6 Department of Biology [Utah]
7 MAGNOME - Models and Algorithms for the Genome
Inria Bordeaux - Sud-Ouest, UB - Université de Bordeaux, CNRS - Centre National de la Recherche Scientifique : UMR5800
8 LaBRI - Laboratoire Bordelais de Recherche en Informatique
9 SEG - Structure et évolution des génomes
10 GENOSCOPE - Genoscope - Centre national de séquençage [Evry]
11 ARN - Architecture et Réactivité de l'ARN
12 IG - Institut de Génomique d'Evry
13 IBITECS - Institut de Biologie et de Technologies de Saclay
14 MABIOVIS - Modèles et algorithmes pour la Bioinformatique et la Visualisation d'informations;
LaBRI - Laboratoire Bordelais de Recherche en Informatique
15 GMGM - Génétique moléculaire, génomique, microbiologie
16 MAP - Microbiologie, adaptation et pathogénie
17 Génomique (Plate-Forme)
18 Department of Membrane Transport [Prague]
19 LCB - Laboratoire de chimie bactérienne
Abstract : Our knowledge on yeast genomes remains largely dominated by the extensive studies on Saccharomyces cerevisiae and the consequences of its ancestral duplication, leaving the evolution of the entire class of hemiascomycetes only partly explored. We concentrate here on five species of Saccharomycetaceae, a large subdivision of hemiascomycetes, that we call "protoploid" because they diverged from the S. cerevisiae lineage prior to its genome duplication. We determined the complete genome sequences of three of these species, Kluyveromyces (Lachancea) thermotolerans and Saccharomyces (Lachancea) kluyveri (two members of the newly described Lachancea clade) and Zygosaccharomyces rouxii. We included in our comparisons the previously available sequences of Klyveromyces lactis and Ashbya (Eremothecium) gossypii. Despite their broad evolutionary range and significant individual variations in each lineage, the five protoploid Saccharomycetaceae share a core repertoire of ca. 3,300 protein families and a high degree of conserved synteny. Synteny blocks were used to define gene orthology and to infer ancestors. Far from representing minimal genomes without redundancy, the five protoploid yeasts contain numerous copies of paralogous genes, either dispersed or in tandem arrays, that, altogether, constitute a third of each genome. Ancient, conserved paralogs as well as novel, lineage-specific paralogs were identified.
Type de document :
Article dans une revue
Genome Research, Cold Spring Harbor Laboratory Press, 2009, 19, pp.1696-1709. 〈10.1101/gr.091546.109〉
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https://hal.inria.fr/inria-00407511
Contributeur : David James Sherman <>
Soumis le : samedi 25 juillet 2009 - 00:06:52
Dernière modification le : vendredi 20 avril 2018 - 15:44:06

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Jean-Luc Souciet, Bernard Dujon, Claude Gaillardin, Mark Johnston, Philippe V Baret, et al.. Comparative genomics of protoploid Saccharomycetaceae.. Genome Research, Cold Spring Harbor Laboratory Press, 2009, 19, pp.1696-1709. 〈10.1101/gr.091546.109〉. 〈inria-00407511〉

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