LIX - Laboratoire d'informatique de l'École polytechnique [Palaiseau], LRI - Laboratoire de Recherche en Informatique, UP11 - Université Paris-Sud - Paris 11, Inria Saclay - Ile de France
1AMIB - Algorithms and Models for Integrative Biology (Algorithmes et modèles pour la Biologie Intégrative
Bâtiment Alan Turing - Campus de l'École Polytechnique - 1 rue Honoré d'Estienne d'Orves - 91120 Palaiseau - France)
3Department of Biology (Boston College 140 Commonwealth Avenue Chestnut Hill, MA 02467 - United States)
BC - Boston College (140 Commonwealth Avenue Chestnut Hill, MA 02467 - United States)
Abstract : Given an input Protein Data Bank file (PDB) for a protein or RNA molecule, LocalMove is a web server that determines an on-lattice representation for the input biomolecule. The web server implements a Markov Chain Monte-Carlo algorithm with simulated annealing to compute an approximate fit for either the coarse-grain model or backbone model on either the cubic or face-centered cubic lattice. LocalMove returns a PDB file as output, as well as dynamic movie of 3D images of intermediate conformations during the computation. The LocalMove server is publicly available at http://bioinformatics.bc.edu/clotelab/localmove/.
